{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:59:39Z","timestamp":1787169579026,"version":"build-2736575974"},"reference-count":20,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2023,1,22]],"date-time":"2023-01-22T00:00:00Z","timestamp":1674345600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vasc Endovascular Surg"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The gold standard for patients with carotid body tumors (CBT) is surgical resection; nevertheless, some patients are unfit for surgery or, for other reasons, could not be operated on. Active surveillance has been known to be a reasonable strategy for these cases. This study aimed to evaluate tumor growth in unoperated patients with CBTs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective review of all unoperated patients with CBT from a single academic hospital diagnosed between 2014 and 2021 was performed. Results of nonparametric testing were presented using the median and ranges for Mann-Whitney-U or Kruskal-Wallis. Significance was defined as a 2-tailed P &lt; .05.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The cohort included a total of 31 patients, with a median age of 60 years (range: 37-80\u00a0years), of which 27 (87.1%) were females. The patients live at a median altitude of 2800\u00a0meters (range: 2756-2980\u00a0meters) above sea level. Twenty (64.5%) patients had Shamblin I tumors, eight (25.8%) patients had Shamblin II tumors, and three (9.7%) patients had Shamblin III tumors. Median CBT volume at diagnosis was 14.1 cm3 (range: .9 - 213.3\u00a0cm\n                      <jats:sup>3<\/jats:sup>\n                      ). Median volume at diagnosis of symptomatic tumors was substantially larger than asymptomatic tumors, 49.2\u00a0cm\n                      <jats:sup>3<\/jats:sup>\n                      vs 7.9 cm\n                      <jats:sup>3<\/jats:sup>\n                      , respectively (P = .03). Median growth of the tumors during a median 15-month follow-up (range: 3-43 months) was 3.3\u00a0cm\n                      <jats:sup>3<\/jats:sup>\n                      (range: 0-199.9\u00a0cm\n                      <jats:sup>3<\/jats:sup>\n                      ). Overall, 77% (n = 24) of the CBTs grew at least 1\u00a0cm\n                      <jats:sup>3<\/jats:sup>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Most patients in the present study had tumor growth by at least 1\u00a0cm\n                      <jats:sup>3<\/jats:sup>\n                      , with a median tumor growth of 3.3\u00a0cm.\n                      <jats:sup>3<\/jats:sup>\n                      In the present study tumor growth was shown to be greater than other low altitude CBT active surveillance studies; therefore, surgical resection should be recommended in patients with CBT living at high altitudes.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15385744231154089","type":"journal-article","created":{"date-parts":[[2023,1,22]],"date-time":"2023-01-22T23:18:35Z","timestamp":1674429515000},"page":"451-455","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["High Altitude Carotid Body Tumors Growth During active Surveillance"],"prefix":"10.1177","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5101-1541","authenticated-orcid":false,"given":"Mauricio","family":"Gonzalez-Urquijo","sequence":"first","affiliation":[{"name":"Tecnologico de Monterrey, School of Medicine and Health Sciences, Monterrey, Nuevo Le\u00f3n, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Hinojosa-Gonzalez","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, School of Medicine and Health Sciences, Monterrey, Nuevo Le\u00f3n, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8548-6833","authenticated-orcid":false,"given":"Mario Alejandro","family":"Fabiani","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, School of Medicine and Health Sciences, Monterrey, Nuevo Le\u00f3n, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirna","family":"Gonz\u00e1lez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, School of Medicine and Health Sciences, Monterrey, Nuevo Le\u00f3n, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8799-8106","authenticated-orcid":false,"given":"Edgar Geovanny","family":"Cardenas-Figueroa","sequence":"additional","affiliation":[{"name":"Hospital de Especialidades Carlos Andrade Mar\u00edn, Quito, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica Alexandra","family":"Rosero-Aguirre","sequence":"additional","affiliation":[{"name":"Hospital de Especialidades Carlos Andrade Mar\u00edn, Quito, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6699-5317","authenticated-orcid":false,"given":"Victor Hugo","family":"Viteri-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Hospital de Especialidades Carlos Andrade Mar\u00edn, Quito, 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