{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T12:56:12Z","timestamp":1780059372844,"version":"3.54.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vasc Endovascular Surg"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Total contact casting (TCC) is used to promote wound closure in diabetic foot ulcers (DFUs); however, this technique is underused today. This study aims to further evaluate the efficacy of TCC in a large cohort, including patients with peripheral artery disease (PAD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective analysis of patients with DFUs who underwent TCC from 2017 to 2021. PAD was defined as absence of pedal pulse or ABI &lt;0.9. Demographic data, DFU characteristics, and peripheral arterial intervention were evaluated. Outcomes included complete healing, healing time, and rate of major amputation. Subgroup analysis was performed on patients undergoing peripheral intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      152 patients underwent TCC. Mean age was 58.8 \u00b1 12.1\u00a0years, 79.6% were male, and 26.3% had PAD. Mean DFU size was 8.27 \u00b1 9.9\u00a0cm\n                      <jats:sup>2<\/jats:sup>\n                      , with mean depth 0.61 \u00b1 0.49\u00a0cm. 112 patients had palpable pedal pulses on the affected extremity (73.7%). Average ABI was 1.12 \u00b1 0.22 (n = 90). Complete healing was observed in 122 (80.3%) patients, with average healing time of 81.5 \u00b1 57.1\u00a0days. Thirteen (8.6%) patients eventually required amputation (3 major). When compared to patients with healed DFUs, those without healing had higher rates of amputation (39.1% vs 3.1%,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001), intervention (43.4% vs 17.8%,\n                      <jats:italic>P<\/jats:italic>\n                      = .006), and noncompliance (39.1% vs 20.2%,\n                      <jats:italic>P<\/jats:italic>\n                      = .046). Thirty-three patients underwent revascularization, undergoing angioplasty (81.8%), atherectomy (63.6%), stent (15.2%), and\/or bypass (9.1%). Interventions were performed in aortoiliac (3.0%), femoropopliteal (45.5%), and tibial (72.7%) segments. Twenty-two (66.7%) patients who underwent revascularization completely healed. Patients requiring revascularization were more likely to have previous intervention (57.6% vs 13.4%,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .0001) and incompressible vessels (36.4% vs 7.6%,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .00001), with lower ABIs (0.94 \u00b1 0.25 vs 1.17 \u00b1 0.18,\n                      <jats:italic>P<\/jats:italic>\n                      = .0008) compared to patients without intervention.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TCC remains an effective option for treatment of DFUs, as most were completely healed. Patients with PAD may benefit from TCC and revascularization, however, healing rates are lower in this cohort, necessitating the need for close observation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15385744241301171","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T09:02:55Z","timestamp":1731402175000},"page":"379-386","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Total Contact Casting Remains an Effective Modality for Treatment of Diabetic Foot Ulcers"],"prefix":"10.1177","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4160-1684","authenticated-orcid":false,"given":"Jason","family":"Zhang","sequence":"first","affiliation":[{"name":"Division of Vascular and Endovascular Surgery, NYU School of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikel","family":"Sadek","sequence":"additional","affiliation":[{"name":"Division of Vascular and Endovascular Surgery, NYU School of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lou","family":"Iannuzzi","sequence":"additional","affiliation":[{"name":"Hyperbaric and Advanced Wound Healing Center, NYU Grossman School of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caron","family":"Rockman","sequence":"additional","affiliation":[{"name":"Division of Vascular and Endovascular Surgery, NYU School of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karan","family":"Garg","sequence":"additional","affiliation":[{"name":"Division of Vascular and Endovascular Surgery, NYU School of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Taffet","sequence":"additional","affiliation":[{"name":"Division of Vascular and Endovascular Surgery, NYU School of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly","family":"Ratner","sequence":"additional","affiliation":[{"name":"Division of Vascular and Endovascular Surgery, NYU School of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Berland","sequence":"additional","affiliation":[{"name":"Division of Vascular and Endovascular Surgery, NYU School of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Maldonado","sequence":"additional","affiliation":[{"name":"Division of Vascular and Endovascular Surgery, NYU School of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn","family":"Jacobowitz","sequence":"additional","affiliation":[{"name":"Division of Vascular and Endovascular Surgery, NYU School of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Ross","sequence":"additional","affiliation":[{"name":"Hyperbaric and Advanced Wound Healing Center, NYU Grossman School of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,11,12]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jccw.2018.05.002"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2021.1.25640"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13047-020-00383-2"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/dme.13054"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.10578"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.4103\/jehp.jehp_907_20"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2013.03.001"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/107110070402500808"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.12.6.384"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.6.1019"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12213"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1708"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2015.10.006"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.4103\/jodp.jodp_14_22"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-0771"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124739"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2013.08.003"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.2337\/dci22-0043"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcot.2021.01.017"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1615439"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.2.243"},{"issue":"2","key":"e_1_3_5_23_2","first-page":"49","article-title":"Total 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