{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T22:43:33Z","timestamp":1781995413736,"version":"3.54.5"},"reference-count":20,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vasc Endovascular Surg"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the clinical, hematological, and anatomical outcomes of rotational atherectomy (RA) combined with drug-coated balloon (DCB) angioplasty compared to DCB alone in patients with femoropopliteal arterial disease, with particular emphasis on inflammatory markers and mid-term vessel patency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective, single-center study included patients who underwent endovascular treatment for femoropopliteal lesions using either RA combined with DCB (RA + DCB) or DCB alone. Demographic characteristics, lesion morphology, neutrophil-to-lymphocyte ratio (NLR), and Doppler ultrasonography (DUS) findings were compared between the two groups. Primary outcomes were residual stenosis, ankle-brachial index (ABI), and mid-term vessel patency. Secondary outcomes included postprocedural NLR changes and clinical symptom evolution during follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 150 patients were included, with 75 treated using RA + DCB and 75 with DCB alone. There were no significant differences in baseline demographics or comorbidities between groups. The RA + DCB group demonstrated a higher prevalence of TASC A lesions and left lower extremity involvement. Postprocedural lymphocyte counts were significantly higher, and NLR values were significantly lower in the RA + DCB group. Additionally, this group exhibited lower residual stenosis rates and significantly higher patency rates at 6 and 12 months. Greater clinical improvement and a higher proportion of asymptomatic patients were observed in the RA + DCB group during follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>RA combined with DCB offers superior vascular and clinical outcomes vs DCB alone, likely due to improved lesion preparation and reduced inflammation. NLR may serve as both a prognostic biomarker and indicator of treatment efficacy in peripheral arterial interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15385744251387577","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T09:14:00Z","timestamp":1760433240000},"page":"125-134","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["The Relationship Between Neutrophil-to-Lymphocyte Ratio and Restenosis in Patients With Femoropopliteal Chronic Total Occlusion Treated With Drug-Coated Balloon Alone Versus Combined Atherectomy and Drug-Coated Balloon"],"prefix":"10.1177","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4228-6233","authenticated-orcid":false,"given":"Hasan","family":"Toz","sequence":"first","affiliation":[{"name":"Bakirkoy Dr. Sadi Konuk Training & Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8731-3787","authenticated-orcid":false,"given":"Yusuf","family":"Kuserli","sequence":"additional","affiliation":[{"name":"Bakirkoy Dr. Sadi Konuk Training & Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcls\u00fcm","family":"T\u00fcrky\u0131lmaz","sequence":"additional","affiliation":[{"name":"Bakirkoy Dr. Sadi Konuk Training & Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8620-9320","authenticated-orcid":false,"given":"Onur Emre","family":"Sat\u0131lm\u0131s","sequence":"additional","affiliation":[{"name":"Bakirkoy Dr. Sadi Konuk Training & Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6881-4439","authenticated-orcid":false,"given":"Ali Aycan","family":"Kavala","sequence":"additional","affiliation":[{"name":"Bakirkoy Dr. Sadi Konuk Training & Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayg\u0131n","family":"T\u00fcrky\u0131lmaz","sequence":"additional","affiliation":[{"name":"Bakirkoy Dr. Sadi Konuk Training & Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,14]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.medcli.2023.06.005"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2021.101082"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.318261"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae372"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-21-01070"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-024-02191-5"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1434580"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2020.4644"},{"issue":"18","key":"e_1_3_4_10_2","first-page":"e895","article-title":"AHA\/ACC\/HFSA guideline for the management of heart failure: a report of the American college of cardiology\/American heart association joint committee on clinical practice guidelines","volume":"145","author":"Heidenreich PA","year":"2022","unstructured":"Heidenreich PA, Bozkurt B, Aguilar D, et al. AHA\/ACC\/HFSA guideline for the management of heart failure: a report of the American college of cardiology\/American heart association joint committee on clinical practice guidelines. 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