{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:44:27Z","timestamp":1777941867440,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vasc Endovascular Surg"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Heparin-induced thrombocytopenia (HIT) is an acquired prothrombotic state from anti-heparin platelet-factor 4 (PF4) mediated activation of platelets. Anti-PF4 assay is used to screen for HIT due to high sensitivity and negative predictive value.\n                    <jats:bold>Case Report:<\/jats:bold>\n                    We present a 74-year-old male that had clinical HIT with false negative anti-PF4 and subsequently positive serotonin release assay (SRA). Delay in cessation of heparin led to recurrent limb thrombosis in the setting of multiple revascularization attempts with a poor outcome.\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    We re-emphasize the importance of clinical presentation in management of patients with suspected HIT.\n                  <\/jats:p>","DOI":"10.1177\/15385744251395139","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T07:16:44Z","timestamp":1762413404000},"page":"358-360","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Heparin-Induced Thrombocytopenia With a False Negative Anti-PF4 Assay"],"prefix":"10.1177","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2346-8082","authenticated-orcid":false,"suffix":"II","given":"Thomas J.","family":"Perry","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery, Cleveland Clinic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan","family":"Cass","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Cleveland Clinic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Ellis","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Cleveland Clinic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Khalifeh","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Cleveland Clinic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,11,5]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2011.10.082"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-04-1546"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199505183322003"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH04-12-0825"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.2147\/JBM.S232648"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1538-7836.2003.00282.x"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V67.1.27.27"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2018.07.001"},{"key":"e_1_3_5_10_2","first-page":"1","article-title":"False-negative platelet factor 4 antibodies and serotonin release assay and the utility of repeat testing in the diagnosis of heparin-induced thrombocytopenia and thrombosis","volume":"2019","author":"Omer T","year":"2019","unstructured":"Omer T, Mullaguri N, George P, Newey CR, False-negative platelet factor 4 antibodies and serotonin release assay and the utility of repeat testing in the diagnosis of heparin-induced thrombocytopenia and thrombosis. Case Rep Hematol. 2019;2019:1-4.","journal-title":"Case Rep Hematol"},{"key":"e_1_3_5_11_2","volume-title":"Heparin-Induced Thrombocytopenia","author":"Nicolas D","year":"2020","unstructured":"Nicolas D, Nicolas S, Hodgens A, et al. Heparin-Induced Thrombocytopenia. Springer; 2020."}],"container-title":["Vascular and Endovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15385744251395139","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15385744251395139","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15385744251395139","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T06:36:34Z","timestamp":1777703794000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15385744251395139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,5]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1177\/15385744251395139"],"URL":"https:\/\/doi.org\/10.1177\/15385744251395139","relation":{},"ISSN":["1538-5744","1938-9116"],"issn-type":[{"value":"1538-5744","type":"print"},{"value":"1938-9116","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,5]]}}}