{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T17:46:33Z","timestamp":1791740793646,"version":"4.3.4"},"reference-count":27,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vasc Endovascular Surg"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Management of Mixed Arterial Venous Leg Ulcers (MAVLU) represents a clinical dilemma. The ideal sequencing of intervention \u2018veins-first\u2019 vs \u2018artery-first\u2019 remains uncertain. With the paucity of current MAVLU guidelines, we evaluated our patients\u2019 preferences to help establish momentum in developing clinical evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a prospective, cross-sectional study to elicit patient preferences using the Discrete Choice Experiment (DCE). The DCE task contained the two options veins-first vs artery-first intervention. The block randomisation method was utilised to provide alternating order of the choice set. Through in-person structured interviews, five main aspects (attributes) of each intervention were discussed to allow comparison (type of anaesthesia, duration and complexity of intervention, associated risks, and post-operative stay). Once the preference has been expressed, patients were asked to rank these attributes in order of importance to indicate their influence on decision-making.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 30 patients of MAVLU reviewed over a 12-month period, 26 were suitable for inclusion. 77% of patients (20\/26) opted for a veins-first approach. The lower procedural risk associated with venous intervention was the most important attribute in the veins-first group. Similarly, most of those who chose the artery-first approach (6\/20) believed that the higher risk profile and complexity or arterial interventions are an unavoidable necessity to achieve ulcer healing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\u2018veins-first\u2019 approach in treating MAVLU was the predominant choice in our case series. Holistic risk-benefit assessment is essential in joint decision making.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15385744261494635","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T10:27:44Z","timestamp":1791455264000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessing Patient Preferences for Management of Mixed Arterial and Venous Leg Ulcers"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5294-6916","authenticated-orcid":false,"given":"Mohammed","family":"Alagha","sequence":"first","affiliation":[{"name":"University of Galway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9683-708X","authenticated-orcid":false,"given":"Abdallah","family":"Alagha","sequence":"additional","affiliation":[{"name":"School of Medicine, University College Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1006-9541","authenticated-orcid":false,"given":"Stewart R.","family":"Walsh","sequence":"additional","affiliation":[{"name":"University of Galway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10198-017-0916-4"},{"key":"e_1_3_3_3_2","unstructured":"FDA. Patient Preference Information \u2013 Voluntary Submission Review in Premarket Approval Applications Humanitarian Device Exemption Applications and De Novo Requests and Inclusion in Decision Summaries and Device Labeling: Guidance for Industry Food and Drug Administration Staff and Other Stakeholders. https:\/\/www.fda.gov\/regulatoryinformation\/search-fda-guidance-documents\/patient-preference-information-voluntary-submission-review-premarket-approvalapplications"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.10.1290"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.300.15.1814"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40271-019-00408-4"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40271-019-00396-5"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2016.04.008"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2016.02.019"},{"key":"e_1_3_3_10_2","unstructured":"National Institute for Health and Care Excellence; 2019 May 22. Available from: https:\/\/www.nice.org.uk\/Media\/Default\/Get-involved\/Meetings-In-Public\/Public-board-meetings\/agenda-and-papers-may-19.pdf. Accessed May 25 2025"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2015.12.010"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2022.04.016"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2010.11.013"},{"key":"e_1_3_3_14_2","unstructured":"Cowie L Bouvy J. Measuring patient preferences: an exploratory study to determine how patient preferences data could be used in health technology assessment (HTA). Myeloma UK. 2019. Available from: https:\/\/www.myeloma.org.uk\/wp-content\/uploa\/ds\/2019\/07\/NICE-Patient-Preferences-Report.pdf. 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