{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:42:01Z","timestamp":1792672921012,"version":"4.5.0"},"reference-count":18,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vasc Endovascular Surg"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Major lower extremity amputations, defined as above-ankle amputations, are morbid and significantly life-changing. Older patients may be more susceptible to poor outcomes. Our goal was to assess the short- and long-term outcomes of major amputations in octogenarians.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective single-center chart review was performed on all octogenarian patients who underwent a major amputation at a safety-net hospital between 2014-2023. Demographics, operative characteristics, postoperative outcomes, and 30-day and 1-year outcomes were collected and analyzed. Multivariable binary logistic regression evaluated factors associated with 1-year mortality. Fisher\u2019s exact test evaluated univariate categorical comparisons because of small cell frequencies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>56 octogenarian patients underwent a major amputation: 96.4% underwent an amputation for chronic limb-threatening ischemia while 3.6% of patients had acute limb ischemia. Above-knee and below-knee amputations accounted for 73.2 and 26.8% of procedures, respectively; 10.6% were guillotine amputations. Intensive care unit (ICU) admission was required in 26.3% of cases, and total mean hospital length of stay (LOS) was 13.7\u00a0days. Postoperatively, 55.4% were discharged to a skilled nursing facility, 17.9% patients to an acute rehab facility, and 12.5% to home with assistance. Thirty-day emergency department use rate was 14.3%, and hospital readmission rate was 12.5%. Most patients (83.9%) were non-ambulatory at 1-year. In-hospital mortality was 8.9%, 30-day mortality was 14.3%, and 1-year mortality was 35.7%. Univariate analyses demonstrated no statistically significant differences among evaluated variables. Multivariable analysis of 1-year mortality was also not statistically significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Major amputations in octogenarians are highly morbid with high ICU utilization and prolonged LOS with frequent discharge to acute care facilities. About one-third of patients are not alive at 1-year. These findings suggest the need to identify opportunities for improvement in this high-risk patient population undergoing amputations, such as early revascularization, aggressive rehabilitation in concert with geriatrician collaboration, medical optimization, and improved goals-of-care discussions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15385744261500878","type":"journal-article","created":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T11:31:03Z","timestamp":1792323063000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes After Major Amputation in Octogenarians"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5781-4051","authenticated-orcid":false,"given":"Kyle","family":"Bui","sequence":"first","affiliation":[{"name":"Boston Medical 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