{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T14:36:51Z","timestamp":1792852611792,"version":"4.5.0"},"reference-count":44,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Key R&D Program of Jining","award":["2023YXNS245"],"award-info":[{"award-number":["2023YXNS245"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["ASSAY and Drug Development Technologies"],"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">\n                      Diabetic peripheral neuropathy (DPN) is a common chronic complication of diabetes that severely impairs quality of life. The Yi-Qi-Bu-Shen Recipe (YQBS) alleviates diabetic complications, but its mechanism against DPN remains unclear. This study aimed to explore the underlying mechanism of YQBS against DPN using network pharmacology and to verify its effects on peripheral nerve injury and modulation of the AGE-RAGE\/NF-\u03baB signaling pathway\n                      <jats:italic toggle=\"yes\">in\u00a0vivo<\/jats:italic>\n                      . Active components of YQBS were computationally screened\n                      <jats:italic toggle=\"yes\">via<\/jats:italic>\n                      the TCMSP database, potential targets were predicted using GeneCards and OMIM, and key pathways were analyzed by KEGG enrichment. Molecular docking was performed to assess binding affinities. In animal experiments, streptozotocin-induced DPN rats were randomized into control, model, low-dose YQBS, and high-dose YQBS groups. After 12 weeks, nerve conduction velocity, sciatic nerve pathology, nerve repair\u2013related proteins, and RAGE\/NF-\u03baB p65 phosphorylation were evaluated. Network pharmacology predicted quercetin, \u03b2-sitosterol, and formononetin as major active components,\n                      <jats:italic toggle=\"yes\">PTGS2<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">NOS2<\/jats:italic>\n                      as core targets, and AGE-RAGE\/PI3K\u2013Akt as key pathways. Molecular docking predicted favorable binding affinities. Animal experiments confirmed that YQBS significantly improved nerve conduction, alleviated nerve damage, upregulated repair proteins, and inhibited RAGE expression and NF-\u03baB p65 phosphorylation. In conclusion, YQBS ameliorates DPN in rats, with suppression of AGE-RAGE\/NF-\u03baB pathway activation.\n                    <\/jats:italic>\n                  <\/jats:p>","DOI":"10.1177\/1540658x261496344","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:43:33Z","timestamp":1792669413000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Yi-Qi-Bu-Shen Recipe Alleviates Diabetic Peripheral Neuropathy: Network Pharmacology Prediction and\n                    <i>In Vivo<\/i>\n                    Evidence"],"prefix":"10.1177","author":[{"given":"Yuanyuan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Neurology, Jining No. 1 People\u2019s Hospital, Jining, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Jining No. 1 People\u2019s Hospital, Jining, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengbo","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Jining No. 1 People\u2019s Hospital, Jining, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Jining No. 1 People\u2019s Hospital, Jining, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0349-0806","authenticated-orcid":false,"given":"Chuanqian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Jining No. 1 People\u2019s Hospital, Jining, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,22]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-00317-7"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2025.112176"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-024-01041-y"},{"key":"e_1_3_3_5_1","volume-title":"StatPearls","author":"Packer CF","year":"2025","unstructured":"4.Packer CF, , Ali SA, , Manna B. Diabetic foot ulcer. In: StatPearls. StatPearls Publishing: Treasure Island, FL; 2025. 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Luteolin improves the impaired nerve functions in diabetic neuropathy: Behavioral and biochemical evidences. 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