{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T07:00:47Z","timestamp":1785481247550,"version":"3.56.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100019311","name":"Northwell Health","doi-asserted-by":"crossref","award":["Katz Institute for Women\u2019s Health Foundation"],"award-info":[{"award-number":["Katz Institute for Women\u2019s Health Foundation"]}],"id":[{"id":"10.13039\/100019311","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Women's Health"],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Despite significant medical and scientific advances, gaps remain in women\u2019s health research across the lifespan. We explore the use of the\n                      <jats:italic toggle=\"yes\">All of Us Research Program Data<\/jats:italic>\n                      set to help close the research gaps for women.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      This paper describes the utility of the\n                      <jats:italic toggle=\"yes\">All of Us<\/jats:italic>\n                      Research Program\u2014a large, longitudinal U.S. cohort of over 800,000 individuals (63% women) representing all 50 states\u2014to advance research in women\u2019s health. Three use cases explore conditions that affect women: (1) disproportionality (hyperthyroidism and osteoporosis), (2) differently (health care access), and (3) uniquely (postpartum hemorrhage). Each use case utilized electronic health records, survey responses, and clinical measurements, and was analyzed with R on the secure cloud-based workbench.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Hyperthyroidism was strongly associated with the development of osteoporosis, suggesting opportunities for additional screening and treatment. Examining access to care, women described barriers including cost, transportation, and caregiving responsibilities. In postpartum hemorrhage of the over 10,000 pregnancies we analyzed, the multivariable linear regression showed that anemia, preeclampsia, obesity, placental abruption, and placenta previa were all significant risk factors. These use cases demonstrate the size and depth of the data and the usefulness for testing hypotheses and identifying areas for screening and prevention for women\u2019s health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>All of Us enables comprehensive, inclusive research into sex-specific health issues. Our analyses show how this dataset fills long-standing gaps by supporting stratified analyses enabling research into women\u2019s health across the lifespan. Researchers can readily access these tools to accelerate science and medical advances for women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15409996261434111","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T04:10:52Z","timestamp":1773979852000},"page":"724-734","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Leveraging the\n                    <i>All of Us<\/i>\n                    Research Program to Advance Women\u2019s Health: Addressing Conditions that Affect Women Differently, Disproportionately, and Uniquely"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2583-4859","authenticated-orcid":false,"given":"Elizabeth","family":"Cohn","sequence":"first","affiliation":[{"name":"School of Medicine, City University of New York, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoda","family":"Anton-Culver","sequence":"additional","affiliation":[{"name":"School of Medicine, University of California, Irvine, Irvine, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth W.","family":"Karlson","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhou","sequence":"additional","affiliation":[{"name":"MGH Center for Precision Psychiatry, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadine","family":"Joffe","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Jeong","family":"Oh","sequence":"additional","affiliation":[{"name":"Northwell Health Feinstein Institutes for Medical Research, Institutes of Health System Science, Manhasset, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, Irvine, Irvine, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karmel","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Federer","sequence":"additional","affiliation":[{"name":"Yale Institutional Review Board, Yale Ventures, New Haven, Connecticut, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie Trentacoste","family":"McNally","sequence":"additional","affiliation":[{"name":"Katz Institute for Women\u2019s Health, New York, New York, USA."},{"name":"Hofstra University Zucker School of Medicine, Hempstead, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nakisa","family":"Pourkey","sequence":"additional","affiliation":[{"name":"IGNITE for the All of Us Research Program, Community Health and Social Medicine, School of Medicine, City University of New York, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Argyrious","family":"Ziogas","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California Irvine, Irvine, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Codruta","family":"Chiuzan","sequence":"additional","affiliation":[{"name":"Institute of Health System Science, Northwell Health Feinstein Institutes for Medical Research, Manhasset, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Scott","family":"Jones","sequence":"additional","affiliation":[{"name":"Community Health and Social Medicine, School of Medicine, City University of New York, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000005841"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.16405"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1992.03490110055029"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182a9ca67"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1712103"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1585884"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-024-03786-3"},{"issue":"7","key":"e_1_3_5_9_2","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1056\/NEJMsr1809937","article-title":"The \u201cAll of Us\u201d research program","volume":"381","author":"Denny JC","year":"2019","unstructured":"Denny JC, , Rutter JL, , Goldstein DB, et al.; All of Us Research Program I. 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