{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T07:00:46Z","timestamp":1785481246909,"version":"3.56.0"},"reference-count":57,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Women's Health"],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To characterize differences between individuals with and without mid-cycle pain in a registry cohort with endometriosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Prospective analysis of data from the Endometriosis Pelvic Pain Interdisciplinary Cohort Data Registry (Clinicaltrials.gov #NCT02911090) at a tertiary referral center in Western Canada.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects:<\/jats:title>\n                    <jats:p>Three hundred forty-five individuals aged 18\u201349 years who: (1) had at least one episode of menstrual bleeding in the last 3 months, (2) attended a baseline initial visit, and (3) subsequently had surgery with histological confirmation of endometriosis between January 2018 and December 2023. Exclusion criteria included (1) previous hysterectomy; (2) hormonal suppressive therapy use in the last 3 months; and (3) missing data on mid-cycle pain, history of hormonal therapy use, or menstrual cycle regularity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Exposures:<\/jats:title>\n                    <jats:p>N\/A.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures:<\/jats:title>\n                    <jats:p>Mid-cycle pain in the last month versus No mid-cycle pain in the last month.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of the 345 participants, 67% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 232) reported mid-cycle pain in the last month. Mid-cycle pain in the last month was significantly associated with higher mean Central Sensitization Inventory score (48 \u00b1 17 versus 36 \u00b1 16,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001) and more months of prior hormonal suppressive therapy use (58 [14\u2013120] versus 26 [0\u2013109],\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.012). Abnormal anatomy at the time of surgery (e.g., endometrioma, ovarian adhesions) was not associated with mid-cycle pain in the last month.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In this endometriosis cohort at a tertiary referral center, most participants reported mid-cycle pain in the last month, which was associated with central sensitization but was not clearly related to endometriosis anatomical distortion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15409996261443813","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T05:37:01Z","timestamp":1777009021000},"page":"790-799","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Mid-Cycle Pain in Endometriosis: Clinical Correlations and Potential Etiological Factors"],"prefix":"10.1177","volume":"35","author":[{"given":"Hannah E.","family":"Rojas","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerilynn C.","family":"Prior","sequence":"additional","affiliation":[{"name":"Women\u2019s Health Research Institute, Vancouver, British Columbia, Canada."},{"name":"Centre for Menstrual Cycle and Ovulation Research, Endocrinology, University of British Columbia, Vancouver, British Columbia, Canada."},{"name":"Endocrinology and Metabolism, Department of Medicine, UBC, Vancouver, British Columbia, Canada."},{"name":"School of Population and Public Health, UBC, Vancouver, British Columbia, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Noga","sequence":"additional","affiliation":[{"name":"Women\u2019s Health Research Institute, Vancouver, British Columbia, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada."},{"name":"Women\u2019s Health Research Institute, Vancouver, British Columbia, Canada."},{"name":"BC Women\u2019s Centre for Pelvic Pain and Endometriosis, Vancouver, British Columbia, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Bedaiwy","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada."},{"name":"Women\u2019s Health Research Institute, Vancouver, British Columbia, Canada."},{"name":"BC Women\u2019s Centre for Pelvic Pain and Endometriosis, Vancouver, British Columbia, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline E.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada."},{"name":"BC Women\u2019s Centre for Pelvic Pain and Endometriosis, Vancouver, British Columbia, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Allaire","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada."},{"name":"Women\u2019s Health Research Institute, Vancouver, British Columbia, Canada."},{"name":"BC Women\u2019s Centre for Pelvic Pain and Endometriosis, Vancouver, British Columbia, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5521-3052","authenticated-orcid":false,"given":"Paul J.","family":"Yong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada."},{"name":"Women\u2019s Health Research Institute, Vancouver, British Columbia, Canada."},{"name":"BC Women\u2019s Centre for Pelvic Pain and Endometriosis, Vancouver, British Columbia, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"key":"e_1_3_3_2_1","unstructured":"1. 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