{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T08:36:32Z","timestamp":1792917392049,"version":"4.5.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Monique Weill-Caulier Trust","id":[{"id":"https:\/\/ror.org\/056cfqf59","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Women's Health"],"published-print":{"date-parts":[[2026,12,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Polycystic ovary syndrome (PCOS) has been associated with adverse pregnancy outcomes, although reported risks vary across studies. Metabolic heterogeneity within PCOS may contribute to this variability. Dysglycemia during pregnancy may identify a subgroup at increased obstetric risk. The study aims to evaluate whether dysglycemia is associated with preeclampsia and other adverse pregnancy outcomes among individuals with PCOS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We performed a secondary analysis of the prospective Fatty Liver in Pregnancy (FLIP) cohort (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 1,321). PCOS was defined by chart review of the electronic health record. Dysglycemia was defined as current or prior gestational diabetes, abnormal glucose tolerance testing, hemoglobin A1c &gt; 5.7% during pregnancy, or pregestational diabetes. Participants were categorized as PCOS with dysglycemia (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 36), PCOS without dysglycemia (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 44), or non-PCOS controls (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 1,238). The primary outcome was preeclampsia. Secondary outcomes included gestational hypertension, preterm birth, abnormal neonatal weight, and neonatal hypoglycemia. Multivariable logistic regression adjusted for maternal age and body mass index.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among 80 individuals with PCOS, 45% had evidence of dysglycemia. Preeclampsia occurred in 33% of those with PCOS and dysglycemia, 7% of those with PCOS without dysglycemia, and 12% of controls (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.005 for PCOS with dysglycemia versus controls). In adjusted analyses, PCOS with dysglycemia was associated with preeclampsia (odds ratio [OR] 2.9; 95% confidence interval [CI]: 1.4\u20136.1), whereas PCOS without dysglycemia was not (adjusted odds ratio [aOR] 0.53; 95% CI: 0.16\u20131.73). PCOS with dysglycemia was also associated with increased preterm birth (OR: 2.3; 95% CI: 1.04\u20135.14), abnormal neonatal weight (OR: 2.87; 95% CI: 1.36\u20136.10), neonatal hypoglycemia (OR: 2.8; 95% CI: 1.38\u20135.77), and any adverse pregnancy outcome (aOR: 4.49; 95% CI: 1.94\u201310.40).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In this prospective cohort, dysglycemia was associated with higher rates of hypertensive and metabolic pregnancy complications among individuals with PCOS. These findings suggest that coexisting dysglycemia may contribute to heterogeneity in obstetric risk among individuals with PCOS and warrant confirmation in larger studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15409996261465139","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T05:54:36Z","timestamp":1782798876000},"page":"1160-1165","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Dysglycemia and Adverse Pregnancy Outcomes Among Individuals with Polycystic Ovary Syndrome"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0082-6879","authenticated-orcid":false,"given":"Cecilia","family":"Katzenstein","sequence":"first","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia","family":"Lange","sequence":"additional","affiliation":[{"name":"Department of Medicine, Brigham and Women\u2019s Hospital, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanette","family":"Rios","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Reproductive Sciences, UCSF, San Francisco, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Meislin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Icahn School of Medicine at Mount Sinai, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Sigel","sequence":"additional","affiliation":[{"name":"Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily J.","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhoda","family":"Sperling","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Icahn School of Medicine at Mount Sinai, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norah","family":"Terrault","sequence":"additional","affiliation":[{"name":"Division of Gastrointestinal and Liver Diseases, Keck School of Medicine of University of South California, Los Angeles, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Stone","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Icahn School of Medicine at Mount Sinai, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatyana","family":"Kushner","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Division of Obstetrics and Gynecology, Weill Cornell Medicine, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49749-1"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d6309"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004863"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.17734"},{"issue":"1","key":"e_1_3_3_6_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.23736\/S2724-606X.21.04758-4","article-title":"Pregnancy outcomes in women with polycystic ovarian syndrome","volume":"74","author":"D\u2019Alterio MN","year":"2022","unstructured":"5.D\u2019Alterio MN, , Sigilli M, , Succu AG, et al. Pregnancy outcomes in women with polycystic ovarian syndrome. Minerva Obstet Gynecol 2022;74(1):45\u201359.","journal-title":"Minerva Obstet Gynecol"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-021-02886-9"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2022.05.026"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmv029"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/569862"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.57"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13061774"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-020-00595-3"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.06.015"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0000000000000769"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14010123"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deac210"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc25-S015"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002501"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-13-92"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002710"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000067719"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2350"},{"issue":"3","key":"e_1_3_3_24_1","first-page":"400","article-title":"Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome","volume":"34","author":"Teede HJ","year":"2019","unstructured":"23.Teede HJ, , Misso ML, , Costello MF, et al. Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome. 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