{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T12:32:05Z","timestamp":1777811525527,"version":"3.51.4"},"reference-count":9,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T00:00:00Z","timestamp":1033430400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2002,10]]},"abstract":"<jats:p>Little is known about the effect of salivary gland function during aging based on gene expression. Recently emerged DNA array technology provides a sensitive, quantitative, rapid approach to the monitoring of the global pattern of gene expression. In this study, we used high-density oligonucleotide arrays to monitor the changes of gene expression levels in the submandibular gland (SMG) by comparing adult mice with elderly adult mice. Of the 1328 genes screened, 160 genes (12.0%) showed more than two-fold changes; 154 (96.3%) of these genes, associated with transcription regulation, transport, signal transduction, and enzymes in the elderly mice, exhibited decreased expression levels. The remaining 6 genes (3.7%) in the elderly mice showed increased expression levels. In mouse SMG, analysis of these data suggests that aging may lead the gene expression to decrease than increase. Thus, DNA array technology can be a powerful tool for the identification of age-associated candidate genes for further analysis in aging.<\/jats:p>","DOI":"10.1177\/154405910208101005","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"679-682","source":"Crossref","is-referenced-by-count":14,"title":["Microarray Analysis of Gene Expression Changes in Aging in Mouse Submandibular Gland"],"prefix":"10.1177","volume":"81","author":[{"given":"K.","family":"Hiratsuka","sequence":"first","affiliation":[{"name":"Department of Biochemistry,"},{"name":"Department of Oral Surgery, Nihon University School of Dentistry at Matsudo, Nishi 2-870-1 Sakae-cho, Matsudo, Chiba 271-8587, Japan; and"},{"name":"Department of Pharmacology, Nihon University School of Medicine, 30 Oyaguchi, Kami-machi Itabashi, Tokyo 173, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Kamino","sequence":"additional","affiliation":[{"name":"Department of Biochemistry,"},{"name":"Department of Oral Surgery, Nihon University School of Dentistry at Matsudo, Nishi 2-870-1 Sakae-cho, Matsudo, Chiba 271-8587, Japan; and"},{"name":"Department of Pharmacology, Nihon University School of Medicine, 30 Oyaguchi, Kami-machi Itabashi, Tokyo 173, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Nagata","sequence":"additional","affiliation":[{"name":"Department of Biochemistry,"},{"name":"Department of Oral Surgery, Nihon University School of Dentistry at Matsudo, Nishi 2-870-1 Sakae-cho, Matsudo, Chiba 271-8587, Japan; and"},{"name":"Department of Pharmacology, Nihon University School of Medicine, 30 Oyaguchi, Kami-machi Itabashi, Tokyo 173, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry,"},{"name":"Department of Oral Surgery, Nihon University School of Dentistry at Matsudo, Nishi 2-870-1 Sakae-cho, Matsudo, Chiba 271-8587, Japan; and"},{"name":"Department of Pharmacology, Nihon University School of Medicine, 30 Oyaguchi, Kami-machi Itabashi, Tokyo 173, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Asai","sequence":"additional","affiliation":[{"name":"Department of Biochemistry,"},{"name":"Department of Oral Surgery, Nihon University School of Dentistry at Matsudo, Nishi 2-870-1 Sakae-cho, Matsudo, Chiba 271-8587, Japan; and"},{"name":"Department of Pharmacology, Nihon University School of Medicine, 30 Oyaguchi, Kami-machi Itabashi, Tokyo 173, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry,"},{"name":"Department of Oral Surgery, Nihon University School of Dentistry at Matsudo, Nishi 2-870-1 Sakae-cho, Matsudo, Chiba 271-8587, Japan; and"},{"name":"Department of Pharmacology, Nihon University School of Medicine, 30 Oyaguchi, Kami-machi Itabashi, Tokyo 173, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Abiko","sequence":"additional","affiliation":[{"name":"Department of Biochemistry,"},{"name":"Department of Oral Surgery, Nihon University School of Dentistry at Matsudo, Nishi 2-870-1 Sakae-cho, Matsudo, Chiba 271-8587, Japan; and"},{"name":"Department of Pharmacology, Nihon University School of Medicine, 30 Oyaguchi, Kami-machi Itabashi, Tokyo 173, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2002,10,1]]},"reference":[{"key":"AUSTIN-AND-SHIELDS-1996","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.135.6.1471"},{"key":"PEDERSEN-ETAL-1985","doi-asserted-by":"publisher","DOI":"10.1177\/00220345850640050801"},{"key":"PURUSHOTHAM-ETAL-1995","doi-asserted-by":"publisher","DOI":"10.1007\/BF01076467"},{"key":"ROMISCH-1999","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.112.23.4185"},{"key":"TAKEDA-ETAL-1997","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(96)00036-8"},{"key":"TYLENDA-ETAL-1988","doi-asserted-by":"publisher","DOI":"10.1177\/00220345880670091501"},{"key":"VISSINK-ETAL-1996","doi-asserted-by":"publisher","DOI":"10.1111\/j.1754-4505.1996.tb00842.x"},{"key":"WU-ETAL-1995","doi-asserted-by":"crossref","unstructured":"Wu AJ, Baum BJ, Ship JA -1995- Extended stimulated parotid and submandibular secretion in a healthy young and old population. 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