{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T12:14:21Z","timestamp":1777810461373,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2003,3,1]],"date-time":"2003-03-01T00:00:00Z","timestamp":1046476800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2003,3]]},"abstract":"<jats:p>Genetic defects responsible for tooth agenesis are only now beginning to be uncovered. MSX1 and PAX9 have been associated with tooth agenesis in mice and humans, but interestingly for humans, these genes are associated with specific missing teeth. Mouse models also show that specific genes contribute to the development of specific types of teeth. A precise description of the phenotype specifying which teeth are missing has become fundamental. Mendelian segregation can be identified in families with tooth agenesis, but heterogenous or multiple genes may be responsible for the development of specific types of teeth agenesis in humans. Data from animal models are still very complex, and the human embryology is still poorly understood. Oral clefts and syndromic forms of tooth agenesis may be the best models for isolated tooth agenesis. In the future, a precise description of the missing teeth in syndromes involving tooth agenesis may be useful.<\/jats:p>","DOI":"10.1177\/154405910308200303","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"162-165","source":"Crossref","is-referenced-by-count":86,"title":["Oral Clefts and Syndromic Forms of Tooth Agenesis as Models for Genetics of Isolated Tooth Agenesis"],"prefix":"10.1177","volume":"82","author":[{"given":"A.R.","family":"Vieira","sequence":"first","affiliation":[{"name":"Department of Pediatrics ML 2182, The University of Iowa, Iowa City, IA 52242;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2003,3,1]]},"reference":[{"key":"ALTMULLER-ETAL-2001","doi-asserted-by":"publisher","DOI":"10.1086\/324069"},{"key":"BEATY-ETAL-2001","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-2797(01)00222-8"},{"key":"BRAYBROOK-ETAL-2001","doi-asserted-by":"publisher","DOI":"10.1038\/ng730"},{"key":"CHI-AND-EPSTEIN-2002","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(01)02594-X"},{"key":"DAVIDSON-1995","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(00)89124-6"},{"key":"FERGUSON-ETAL-1998","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.16.2636"},{"key":"FERGUSON-ETAL-2000","doi-asserted-by":"crossref","unstructured":"Ferguson CA, Tucker AS, Sharpe PT -2000- Temporospatial cell interactions regulating mandibular and maxillary arch patterning. Development 127:403\u2013412.","DOI":"10.1242\/dev.127.2.403"},{"key":"FERGUSON-ETAL-2001","doi-asserted-by":"crossref","unstructured":"Ferguson CA, Tucker AS, Heikinheimo K, Nomura M, Oh P, Li E,\n                      et al\n                      .2001- The role of effectors of the activin signalling pathway, activin receptors IIA and IIB, and Smad2, in patterning of tooth development. Development 128:4605\u20134613.","DOI":"10.1242\/dev.128.22.4605"},{"key":"FRAZIER-BOWERS-ETAL-2002","doi-asserted-by":"publisher","DOI":"10.1177\/0810129"},{"key":"JONES-1997","unstructured":"Jones KL -1997- Smith\u2019s recognizable patterns of human malformation. 5th rev. ed. Philadelphia: W.B. Saunders."},{"key":"JOWETT-ETAL-1993","doi-asserted-by":"crossref","unstructured":"Jowett AK, Vainio S, Ferguson MW, Sharpe PT, Thesleff I -1993- Epithelial-mesenchymal interactions are required for msx 1 and msx 2 gene expression in the developing murine molar tooth. Development 117:461\u2013470.","DOI":"10.1242\/dev.117.2.461"},{"key":"JUMLONGRAS-ETAL-2001","doi-asserted-by":"publisher","DOI":"10.1086\/321271"},{"key":"KAARTINEN-ETAL-1995","doi-asserted-by":"publisher","DOI":"10.1038\/ng1295-415"},{"key":"LARSON-ETAL-1998","doi-asserted-by":"publisher","DOI":"10.1080\/02844319850158831"},{"key":"LIDRAL-AND-REISING-2002","doi-asserted-by":"publisher","DOI":"10.1177\/154405910208100410"},{"key":"LIDRAL-ETAL-1998","doi-asserted-by":"publisher","DOI":"10.1086\/301956"},{"key":"MACKENZIE-ETAL-1991A","doi-asserted-by":"crossref","unstructured":"MacKenzie A, Leeming GL, Jowett AK, Ferguson MW, Sharpe PT -1991a- The homeobox gene Hox 7.1 has specific regional and temporal expression patterns during early murine craniofacial embryogenesis, especially tooth development in vivo and in vitro. Development 111:269\u2013285.","DOI":"10.1242\/dev.111.2.269"},{"key":"MACKENZIE-ETAL-1991B","doi-asserted-by":"crossref","unstructured":"MacKenzie A, Ferguson MW, Sharpe PT -1991b- Hox-7 expression during murine craniofacial development. Development 113:601\u2013611.","DOI":"10.1242\/dev.113.2.601"},{"key":"MATZUK-ETAL-1995A","doi-asserted-by":"publisher","DOI":"10.1038\/374354a0"},{"key":"MATZUK-ETAL-1995B","doi-asserted-by":"publisher","DOI":"10.1038\/374356a0"},{"key":"MURRAY-ETAL-1990","unstructured":"Murray JC, Nishimura DY, Buetow KH, Ardinger HH, Spence MA, Sparkes RS,\n                      et al\n                      .1990- Linkage of an autosomal dominant clefting syndrome -Van der Woude- to loci on chromosome 1q. Am J Hum Genet 46:486\u2013491."},{"key":"NIEMINEN-ETAL-1995","doi-asserted-by":"crossref","unstructured":"Nieminen P, Arte S, Pirinen S, Peltonen L, Thesleff I -1995- Gene defect in hypodontia: exclusion of MSX1 and MSX2 as candidate genes. Hum Genet 96:305\u2013308.","DOI":"10.1007\/BF00210412"},{"key":"NIEMINEN-ETAL-2001","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200715"},{"key":"OH-AND-LI-1997","doi-asserted-by":"publisher","DOI":"10.1101\/gad.11.14.1812"},{"key":"PETERS-ETAL-1998","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.17.2735"},{"key":"PROETZEL-ETAL-1995","doi-asserted-by":"publisher","DOI":"10.1038\/ng1295-409"},{"key":"RAO-2001","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2660(01)42012-8"},{"key":"SATOKATA-AND-MAAS-1994","doi-asserted-by":"publisher","DOI":"10.1038\/ng0494-348"},{"key":"SCAREL-ETAL-2000","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(20000619)92:5<346::AID-AJMG10>3.0.CO;2-A"},{"key":"SCHINZEL-AND-KLAUSLER-1986","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.23.4.291"},{"key":"SOZEN-ETAL-2001","doi-asserted-by":"publisher","DOI":"10.1038\/ng740"},{"key":"STOCKTON-ETAL-2000","doi-asserted-by":"publisher","DOI":"10.1038\/71634"},{"key":"SUZUKI-ETAL-2000","doi-asserted-by":"publisher","DOI":"10.1038\/78119"},{"key":"TERWILLIGER-AND-GORING-2000","unstructured":"Terwilliger JD, Goring HH -2000- Gene mapping in the 20th and 21st centuries: statistical methods, data analysis, and experimental design. Hum Biol 72:63\u2013132."},{"key":"THOMAS-ETAL-1997","doi-asserted-by":"crossref","unstructured":"Thomas BL, Tucker AS, Qiu M, Ferguson CA, Hardcastle Z, Rubenstein JL,\n                      et al\n                      .1997- Role of\n                      Dlx-1\n                      and\n                      Dlx-2\n                      genes in patterning of the murine dentition. Development 124:4811\u20134818.","DOI":"10.1242\/dev.124.23.4811"},{"key":"THOMAS-ETAL-2000","doi-asserted-by":"crossref","unstructured":"Thomas BL, Liu JK, Rubenstein JL, Sharpe PT -2000- Independent regulation of Dlx2 expression in the epithelium and mesenchyme of the first branchial arch. Development 127:217\u2013224.","DOI":"10.1242\/dev.127.2.217"},{"key":"TRUMPP-ETAL-1999","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.23.3136"},{"key":"VAN-DEN-BOOGAARD-ETAL-2000","doi-asserted-by":"publisher","DOI":"10.1038\/74155"},{"key":"VASTARDIS-ETAL-1996","doi-asserted-by":"publisher","DOI":"10.1038\/ng0896-417"},{"key":"ZHANG-ETAL-1997","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.17.5.2920"}],"container-title":["Journal of Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/154405910308200303","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/154405910308200303","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/154405910308200303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:00:05Z","timestamp":1777496405000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/154405910308200303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,3]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,3]]}},"alternative-id":["10.1177\/154405910308200303"],"URL":"https:\/\/doi.org\/10.1177\/154405910308200303","relation":{},"ISSN":["0022-0345","1544-0591"],"issn-type":[{"value":"0022-0345","type":"print"},{"value":"1544-0591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,3]]}}}