{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:30:51Z","timestamp":1782513051294,"version":"3.54.5"},"reference-count":27,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2003,5,1]],"date-time":"2003-05-01T00:00:00Z","timestamp":1051747200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2003,5]]},"abstract":"<jats:p>External apical root resorption (EARR) is a common orthodontic treatment sequela. Previous studies implicate a substantial genetic component for EARR. Using a candidate gene approach, we investigated possible linkage of EARR associated with orthodontic treatment with the TNSALP, TNF \u03b1 , and TNFRSF11A gene loci. The sample was comprised of 38 American Caucasian families with a total of 79 siblings who completed comprehensive orthodontic treatment. EARR was assessed by means of pre- and post-treatment radiographs. Buccal swab cells were collected for extraction and analysis of DNA. No evidence of linkage was found with EARR and the TNF \u03b1 and TNSALP genes. Non-parametric sibling pair linkage analysis identified evidence of linkage (LOD = 2.5; p = 0.02) of EARR affecting the maxillary central incisor with the microsatellite marker D18S64 (tightly linked to TNFRSF11A). This indicates that the TNFRSF11A locus, or another tightly linked gene, is associated with EARR.<\/jats:p>","DOI":"10.1177\/154405910308200506","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"356-360","source":"Crossref","is-referenced-by-count":136,"title":["Genetic Predisposition to External Apical Root Resorption in Orthodontic                Patients: Linkage of Chromosome-18 Marker"],"prefix":"10.1177","volume":"82","author":[{"given":"R.A.","family":"Al-Qawasmi","sequence":"first","affiliation":[{"name":"Department of Oral Facial Development, Indiana University School of\r               Dentistry, 1121 West Michigan Street, Indianapolis, IN 46202-5186, USA;"},{"name":"Department of Medical and Molecular Genetics, Indiana University\r               School of Medicine, Indianapolis, IN, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"J.K.","family":"Hartsfield","sequence":"additional","affiliation":[{"name":"Department of Oral Facial Development, Indiana University School of\r               Dentistry, 1121 West Michigan Street, Indianapolis, IN 46202-5186, USA;"},{"name":"Department of Medical and Molecular Genetics, Indiana University\r               School of Medicine, Indianapolis, IN, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.T.","family":"Everett","sequence":"additional","affiliation":[{"name":"Department of Oral Facial Development, Indiana University School of\r               Dentistry, 1121 West Michigan Street, Indianapolis, IN 46202-5186, USA;"},{"name":"Department of Medical and Molecular Genetics, Indiana University\r               School of Medicine, Indianapolis, IN, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Flury","sequence":"additional","affiliation":[{"name":"Department of Oral Facial Development, Indiana University School of\r               Dentistry, 1121 West Michigan Street, Indianapolis, IN 46202-5186, USA;"},{"name":"Department of Medical and Molecular Genetics, Indiana University\r               School of Medicine, Indianapolis, IN, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oral Facial Development, Indiana University School of\r               Dentistry, 1121 West Michigan Street, Indianapolis, IN 46202-5186, USA;"},{"name":"Department of Medical and Molecular Genetics, Indiana University\r               School of Medicine, Indianapolis, IN, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.M.","family":"Foroud","sequence":"additional","affiliation":[{"name":"Department of Oral Facial Development, Indiana University School of\r               Dentistry, 1121 West Michigan Street, Indianapolis, IN 46202-5186, USA;"},{"name":"Department of Medical and Molecular Genetics, Indiana University\r               School of Medicine, Indianapolis, IN, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.V.","family":"Macri","sequence":"additional","affiliation":[{"name":"Department of Oral Facial Development, Indiana University School of\r               Dentistry, 1121 West Michigan Street, Indianapolis, IN 46202-5186, USA;"},{"name":"Department of Medical and Molecular Genetics, Indiana University\r               School of Medicine, Indianapolis, IN, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.E.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Oral Facial Development, Indiana University School of\r               Dentistry, 1121 West Michigan Street, Indianapolis, IN 46202-5186, USA;"},{"name":"Department of Medical and Molecular Genetics, Indiana University\r               School of Medicine, Indianapolis, IN, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2003,5,1]]},"reference":[{"key":"ABECASIS-ETAL-2000","doi-asserted-by":"publisher","DOI":"10.1086\/302698"},{"key":"AL-QAWASMI-ETAL-2003","doi-asserted-by":"publisher","DOI":"10.1067\/mod.2003.42"},{"key":"ALHASHIMI-ETAL-2001","doi-asserted-by":"publisher","DOI":"10.1067\/mod.2001.110809"},{"key":"ANDERSON-ETAL-1997","doi-asserted-by":"publisher","DOI":"10.1038\/36593"},{"key":"BEERTSEN-AND-VAN-DEN-BOS-1991","doi-asserted-by":"publisher","DOI":"10.1177\/00220345910700030401"},{"key":"BEERTSEN-ETAL-1999","doi-asserted-by":"publisher","DOI":"10.1177\/00220345990780060501"},{"key":"DAHLBERG-1940","unstructured":"Dahlberg G -1940- Statistical methods\n               for medical and biological students. 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