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The purpose of this study was to compare the amount of root resorption associated with a normal and a hypofunctional periodontium in rats during experimental tooth movement caused by heavy continuous force. The mandibular first molar was induced into a non-occluding condition in the hypofunctional periodontium group. Mesial orthodontic force was applied by means of 50-gram-force closed-coil springs for 15 days in both groups. The active root-resorption lacunae from histological sections, identified by tartrate-resistant acid phosphatase, were measured in terms of length, depth, and area. The results showed that the amount of root resorption was significantly greater in teeth with a hypofunctional periodontium than in those with a normal periodontium (p &lt; 0.05). These results suggest that orthodontic movement of non-occluding teeth should be performed with caution.<\/jats:p>","DOI":"10.1177\/154405910308200616","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"486-490","source":"Crossref","is-referenced-by-count":35,"title":["Root Resorption Related to Hypofunctional Periodontium in Experimental Tooth Movement"],"prefix":"10.1177","volume":"82","author":[{"given":"S.","family":"Sringkarnboriboon","sequence":"first","affiliation":[{"name":"Orthodontic Science, Department of Orofacial Development and Function, Division of Oral Health Science, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Orthodontic Science, Department of Orofacial Development and Function, Division of Oral Health Science, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Soma","sequence":"additional","affiliation":[{"name":"Orthodontic Science, Department of Orofacial Development and Function, Division of Oral Health Science, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2003,6,1]]},"reference":[{"key":"BAROUKH-ETAL-2000","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(00)00372-0"},{"key":"BONDEVIK-1984","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/6.3.205"},{"key":"BREZNIAK-AND-WASSERSTEIN-1993","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-5406(05)81763-9"},{"key":"BRUDVIK-AND-RYGH-1994","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/16.4.249"},{"key":"COOPER-AND-SIMS-1989","doi-asserted-by":"publisher","DOI":"10.2478\/aoj-1989-0022"},{"key":"DOMON-ETAL-1999","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(99)00091-6"},{"key":"HARRIS-AND-BUTLER-1992","doi-asserted-by":"publisher","DOI":"10.1016\/0889-5406(92)70002-R"},{"key":"JEON-ETAL-1999","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-5406(99)70328-8"},{"key":"KAMEYAMA-ETAL-2002","doi-asserted-by":"publisher","DOI":"10.3353\/omp.7.1"},{"key":"KAMEYAMA-ETAL-1994","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1994.tb01099.x"},{"key":"KANEKO-ETAL-2001","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2001.00607.x"},{"key":"KING-AND-FISCHLSCHWEIGER-1982","doi-asserted-by":"publisher","DOI":"10.1177\/00220345820610062501"},{"key":"KOHNO-ETAL-2002","doi-asserted-by":"publisher","DOI":"10.1093\/ortho.29.2.129"},{"key":"KOIKE-1996","doi-asserted-by":"publisher","DOI":"10.2329\/perio.38.1"},{"key":"KRONFELD-1931","doi-asserted-by":"crossref","unstructured":"Kronfeld R -1931- Histologic study of the influence of function on the human periodontal membrane. 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