{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T11:58:49Z","timestamp":1791028729079,"version":"4.1.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2003,9,1]],"date-time":"2003-09-01T00:00:00Z","timestamp":1062374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:p>Matrix metalloproteinases are involved in the regulation of bone remodeling. The hypothesis that matrix metalloproteinase inhibitors may be useful for experimentally limiting orthodontic tooth movement, a process involving perturbations of normal bone remodeling, was tested. General matrix metalloproteinase inhibitors limited the resorption of bone slices by mouse marrow cultures stimulated by calcitriol, parathyroid hormone, and basic-fibroblast growth factor. Pre-coating dentin slices with short arginine-glycine aspartic acid (RGD) peptides, but not arginine-glycine-glutamic acid (RGE) controls, restored bone resorption in the presence of matrix metalloproteinase inhibitors. Orthodontic tooth movement was inhibited by local delivery of Ilomastat, a general matrix metalloproteinase inhibitor, with the use of ethylene-vinyl-acetate (ELVAX) 40, a non-biodegradable, non-inflammatory sustained-release polymer. This study shows that orthodontic tooth movement can be inhibited with the use of matrix metalloproteinase inhibitors, and suggests a mechanistic link between matrix metalloproteinase activity and the production of RGD peptides.<\/jats:p>","DOI":"10.1177\/154405910308200906","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"687-691","source":"Crossref","is-referenced-by-count":47,"title":["Effects of Matrix Metalloproteinase Inhibitors on Bone Resorption and Orthodontic Tooth Movement"],"prefix":"10.1177","volume":"82","author":[{"given":"L.S.","family":"Holliday","sequence":"first","affiliation":[{"name":"Department of Orthodontics, College of Dentistry, University of Florida, Box 100444, JHMHC, Gainesville, FL 32610-0444;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Vakani","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, College of Dentistry, University of Florida, Box 100444, JHMHC, Gainesville, FL 32610-0444;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Archer","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, College of Dentistry, University of Florida, Box 100444, JHMHC, Gainesville, FL 32610-0444;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Dolce","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, College of Dentistry, University of Florida, Box 100444, JHMHC, Gainesville, FL 32610-0444;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2003,9,1]]},"reference":[{"key":"BLAIR-ETAL-1989","doi-asserted-by":"publisher","DOI":"10.1126\/science.2528207"},{"key":"DARNEY-1994","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(94)05016-7"},{"key":"DELAISSE-ETAL-2000","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(99)00230-2"},{"key":"DOMON-ETAL-1999","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(99)00091-6"},{"key":"ENGSIG-ETAL-2000","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.151.4.879"},{"key":"FENG-ETAL-2001","doi-asserted-by":"publisher","DOI":"10.1172\/JCI12040"},{"key":"FISHER-ETAL-1993","doi-asserted-by":"publisher","DOI":"10.1210\/endo.132.3.8440195"},{"key":"FOLKMAN-ETAL-1966","doi-asserted-by":"publisher","DOI":"10.1126\/science.154.3745.148"},{"key":"HOLLIDAY-ETAL-1995","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.32.18983"},{"key":"HOLLIDAY-ETAL-1997","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.35.22053"},{"key":"HOLLIDAY-ETAL-2003","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-002-1008-7"},{"key":"HOLMBECK-ETAL-1999","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80064-1"},{"key":"KING-AND-HOLTROP-1975","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.66.2.445"},{"key":"KING-ETAL-1991","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(91)90029-I"},{"key":"LACEY-ETAL-1998","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81569-X"},{"key":"LANGER-AND-FOLKMAN-1976","doi-asserted-by":"publisher","DOI":"10.1038\/263797a0"},{"key":"LI-ETAL-1991","unstructured":"Li WW, Grayson G, Folkman J, D\u2019Amore PA -1991- Sustained-release endotoxin. A model for inducing corneal neovascularization. Invest Ophthalmol Vis Sci 32:2906\u2013291"},{"key":"LIN-ETAL-2003","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.1.39"},{"key":"MCHUGH-ETAL-2000","doi-asserted-by":"publisher","DOI":"10.1172\/JCI8905"},{"key":"REDLICH-ETAL-2001","doi-asserted-by":"publisher","DOI":"10.1177\/00220345010800121101"},{"key":"RODAN-1998","doi-asserted-by":"crossref","unstructured":"Rodan GA -1998- Control of bone formation and resorption: biological and clinical perspective. J Cell Biochem Suppl 30\u201331:55\u201361.","DOI":"10.1002\/(SICI)1097-4644(1998)72:30\/31+<55::AID-JCB9>3.0.CO;2-R"},{"key":"RODY-ETAL-2001","doi-asserted-by":"publisher","DOI":"10.1067\/mod.2001.118623"},{"key":"RUOSLAHTI-AND-PIERSCHBACHER-1987","doi-asserted-by":"publisher","DOI":"10.1126\/science.2821619"},{"key":"RYGH-AND-REITAN-1972","unstructured":"Rygh P, Reitan K -1972- Ultrastructural changes in the periodontal ligament incident to orthodontic tooth movement. Trans Eur Orthod Soc :393\u2013405."},{"key":"SATO-ETAL-1997","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.110.5.589"},{"key":"SCHULTZ-ETAL-1992","unstructured":"Schultz GS, Strelow S, Stern GA, Chegini N, Grant MB, Galardy RE,\n                      et al.\n                      -1992- Treatment of alkali-injured rabbit corneas with a synthetic inhibitor of matrix metalloproteinases. Invest Ophthalmol Vis Sci 33:3325\u20133331."},{"key":"SHIGA-ETAL-2003","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.1.67"},{"key":"WINDING-ETAL-2002","unstructured":"Winding B, NicAmhlaoibh R, Misander H, Hoegh-Andersen P, Andersen TL, Holst-Hansen C,\n                      et al.\n                      -2002- Synthetic matrix metalloproteinase inhibitors inhibit growth of established breast cancer osteolytic lesions and prolong survival in mice. Clin Cancer Res 8:1932\u20131939."},{"key":"WOESSNER-1991","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.5.8.1850705"},{"key":"ZHAO-ETAL-1999","doi-asserted-by":"publisher","DOI":"10.1172\/JCI5481"}],"container-title":["Journal of Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/154405910308200906","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/154405910308200906","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/154405910308200906","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:00:25Z","timestamp":1777496425000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/154405910308200906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,9]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2003,9]]}},"alternative-id":["10.1177\/154405910308200906"],"URL":"https:\/\/doi.org\/10.1177\/154405910308200906","relation":{},"ISSN":["0022-0345","1544-0591"],"issn-type":[{"value":"0022-0345","type":"print"},{"value":"1544-0591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,9]]}}}