{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:10:56Z","timestamp":1791357056721,"version":"4.3.1"},"reference-count":30,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2003,9,1]],"date-time":"2003-09-01T00:00:00Z","timestamp":1062374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:p>Gingival epithelium is a site of active trafficking of Langerhans cells (LCs), while the lamina propria in chronic periodontitis (CP) contains CD83+ mature dendritic cells (mDCs) and CD4+ T-cells. The immune cells that contribute to the mDCs, and whether mDCs engage with T-cells in situ, are unclear. Using several immunohistochemical approaches, combined with fluorescence-, light-, and scanning laser confocal-microscopy, we show that, in addition to LCs, the gingiva contains dermal DCs (DDCs) in the lamina propria; moreover, DDCs increase in number during CP. Furthermore, DDCs, LCs, and B-cells co-express CD83 in CP and contribute to the mDC pool. Double-staining for CD83 and CD4 revealed that mDCs associate with clusters of CD4+ T-cells in the lamina propria. Analysis of these data suggests that multiple DC subsets mature in the gingiva and that mature DCs engage in antigen presentation with T-cells in chronic periodontitis.<\/jats:p>","DOI":"10.1177\/154405910308200915","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"736-741","source":"Crossref","is-referenced-by-count":94,"title":["Multiple Dendritic Cell (DC) Subpopulations in Human Gingiva and Association of Mature DCs with CD4+ T-cells\n                    <i>in situ<\/i>"],"prefix":"10.1177","volume":"82","author":[{"given":"R.","family":"Jotwani","sequence":"first","affiliation":[{"name":"Department of Periodontics, 110 Rockland Hall, School of Dental Medicine, State University of New York at Stony Brook, Stony Brook, NY 11794-8703;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.W.","family":"Cutler","sequence":"additional","affiliation":[{"name":"Department of Periodontics, 110 Rockland Hall, School of Dental Medicine, State University of New York at Stony Brook, Stony Brook, NY 11794-8703;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2003,9,1]]},"reference":[{"key":"ALVAREZ-ETAL-2002","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.13.6841-6844.2002"},{"key":"BAKER-ETAL-2001","doi-asserted-by":"publisher","DOI":"10.1080\/00016350152509247"},{"key":"BANCHEREAU-AND-STEINMAN-1998","doi-asserted-by":"publisher","DOI":"10.1038\/32588"},{"key":"BANCHEREAU-ETAL-2000","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.18.1.767"},{"key":"CIRRINCIONE-ETAL-2002","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.1.45"},{"key":"COLMENARES-ETAL-2002","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M205270200"},{"key":"CUTLER-ETAL-1999","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1999.tb02274.x"},{"key":"CUTLER-ETAL-2001","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.8.4703-4708.2001"},{"key":"GEIJTENBEEK-ETAL-2000","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80694-7"},{"key":"GEMMELL-ETAL-2002","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-302X.2002.170609.x"},{"key":"GIROLOMONI-ETAL-2002","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(01)02125-1"},{"key":"HAWIGER-ETAL-2001","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.6.769"},{"key":"JAMESON-ETAL-2002","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.4.1866-1875.2002"},{"key":"JOTWANI-ETAL-2001","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.8.4693"},{"key":"KATOU-ETAL-2000","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64756-6"},{"key":"KATOU-ETAL-2001","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64077-1"},{"key":"LIU-2001","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00456-1"},{"key":"MACDONALD-AND-JOHNSTON-2000","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.2.914-922.2000"},{"key":"MAHANONDA-ETAL-2002","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2002.00664.x"},{"key":"MOUGHAL-ETAL-1992","unstructured":"Moughal NA, Adonogianaki E, Kinane DF -1992- Langerhans cell dynamics in human gingiva during experimentally induced inflammation. 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