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The purpose of this double-blind, placebo-controlled, crossover study was to determine age-related differences in salivary response to an anti-sialogogue (glycopyrrolate). Thirty-six healthy subjects (18 young - 20-38 yrs; 18 older - 60-77 yrs) received 4.0 \u03bcg\/kg IV glycopyrrolate. Parotid and submandibular\/sublingual saliva samples and xerostomia questionnaire responses were collected. Variables calculated for each subject were: times to initial and maximum suppression and xerostomic complaint; time to recovery; and durations of suppression and complaint. Salivary function was more adversely affected in older persons. There were no consistent age-associated questionnaire response differences. These findings suggest that salivary gland output is more adversely affected by an anti-sialogogue in healthy older vs. younger adults, supporting the secretory reserve hypothesis of salivary function.<\/jats:p>","DOI":"10.1177\/154405910308201016","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"844-848","source":"Crossref","is-referenced-by-count":87,"title":["Aging and Secretory Reserve Capacity of Major Salivary Glands"],"prefix":"10.1177","volume":"82","author":[{"given":"E.M.","family":"Ghezzi","sequence":"first","affiliation":[{"name":"University of Michigan School of Dentistry, Department of Cariology, Restorative Sciences, and Endodontics, Ann Arbor;"},{"name":"New York University College of Dentistry, Department of Oral Medicine, and Bluestone Center for Clinical Research, 421 First Avenue, 2nd Floor, New York, NY 10010-4086, USA;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.A.","family":"Ship","sequence":"additional","affiliation":[{"name":"University of Michigan School of Dentistry, Department of Cariology, Restorative Sciences, and Endodontics, Ann Arbor;"},{"name":"New York University College of Dentistry, Department of Oral Medicine, and Bluestone Center for Clinical Research, 421 First Avenue, 2nd Floor, New York, NY 10010-4086, USA;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2003,10,1]]},"reference":[{"key":"ALI-MELKKILA-ETAL-1989","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1989.tb02956.x"},{"key":"ALI-MELKKILA-ETAL-1991","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1991.tb03324.x"},{"key":"ATKINSON-AND-WU-1994","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1994.0059"},{"key":"BAUM-ETAL-1992","doi-asserted-by":"publisher","DOI":"10.1177\/10454411920040010401"},{"key":"COWMAN-ETAL-1994","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/49.5.B208"},{"key":"DAWES-1972","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1972.sp009721"},{"key":"DIGIOVANNA-1994","unstructured":"DiGiovanna AG, editor -1994- Introduction. 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