{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:10:48Z","timestamp":1790982648358,"version":"4.1.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2003,12,1]],"date-time":"2003-12-01T00:00:00Z","timestamp":1070236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:p>Periodontitis has been shown to increase the systemic inflammatory response, which has been implicated in atherosclerosis and cerebrovascular events. We hypothesized an association between periodontitis or edentulism and Stroke\/TIA in the ARIC Study. Data on 9415 dentate and 1491 edentulous adults included demographics, cardiovascular outcomes, lifestyle, laboratory measures, and, for 6436 of the dentate, a dental examination. The dependent variable was Stroke\/TIA, and the exposure was extent (%) of attachment level 3+ millimeters (AL). Quartiles of AL and edentulism were compared for Stroke\/TIA using odds ratios (OR) and 95% confidence intervals (CI), and confounders were controlled by logistic regression. Stroke\/TIA was prevalent in 13.5% of periodontal examinees, 15.6% of dentate non-examinees, and 22.5% of edentulous persons. The highest quartile of AL (OR 1.3, CI 1.02-1.7) and edentulism (OR 1.4, CI 1.5-2.0) were associated with Stroke\/TIA.<\/jats:p>","DOI":"10.1177\/154405910308201212","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"998-1001","source":"Crossref","is-referenced-by-count":113,"title":["Relationship of Periodontal Disease and Edentulism to Stroke\/TIA"],"prefix":"10.1177","volume":"82","author":[{"given":"J.R.","family":"Elter","sequence":"first","affiliation":[{"name":"School of Dentistry, CB#7450, University of North Carolina, Chapel Hill, NC 27599-7450, USA; and"},{"name":"Wake Forest University Bowman Gray School of Medicine;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Offenbacher","sequence":"additional","affiliation":[{"name":"School of Dentistry, CB#7450, University of North Carolina, Chapel Hill, NC 27599-7450, USA; and"},{"name":"Wake Forest University Bowman Gray School of Medicine;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.F.","family":"Toole","sequence":"additional","affiliation":[{"name":"School of Dentistry, CB#7450, University of North Carolina, Chapel Hill, NC 27599-7450, USA; and"},{"name":"Wake Forest University Bowman Gray School of Medicine;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.D.","family":"Beck","sequence":"additional","affiliation":[{"name":"School of Dentistry, CB#7450, University of North Carolina, Chapel Hill, NC 27599-7450, USA; and"},{"name":"Wake Forest University Bowman Gray School of Medicine;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2003,12,1]]},"reference":[{"key":"ANSELL-2000","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-000-0101-5"},{"key":"ARIC-INVESTIGATORS-1989","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115184"},{"key":"BECK-ETAL-1996","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1996.67.10s.1123"},{"key":"BECK-ETAL-2001","doi-asserted-by":"publisher","DOI":"10.1161\/hq1101.097803"},{"key":"BECKETT-2001","doi-asserted-by":"publisher","DOI":"10.1177\/174182670100800503"},{"key":"GRAU-ETAL-1997","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.9.1724"},{"key":"HANKEY-2000","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2000.tb124020.x"},{"key":"HOWELL-ETAL-2001","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)01130-X"},{"key":"JOSHIPURA-ETAL-1998","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1998.3.1.175"},{"key":"KOLOMINSKY-RABAS-ETAL-2001","doi-asserted-by":"publisher","DOI":"10.1161\/hs1201.100209"},{"key":"MCDONNELL-ETAL-2000","doi-asserted-by":"publisher","DOI":"10.1007\/BF03173526"},{"key":"NATIONAL-INSTITUTE-OF-NEUROLOGICAL-DISEASES-AND-STROKE-2002A","unstructured":"National Institute of Neurological Diseases and Stroke -2002a- NINDS Stroke Information Page: NINDS. http:\/\/www.ninds.nih.gov\/health_and_medical\/disorders\/tia_doc.htm"},{"key":"NATIONAL-INSTITUTE-OF-NEUROLOGICAL-DISEASES-AND-STROKE-2002B","unstructured":"National Institute of Neurological Diseases and Stroke -2002b- Questions and answers about stroke. http:\/\/www.ninds.nih.gov\/health_and_medical\/pubs\/stroke_backgrounder.htm"},{"key":"OFFENBACHER-1996","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1996.1.1.821"},{"key":"SACCO-2002","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-8902.2001.00035.x"},{"key":"SYRJANEN-ETAL-1989","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1989.tb00060.x"},{"key":"THE-ARIC-INVESTIGATORS-1987A","unstructured":"The ARIC Investigators -1987a- ARIC Manual of Operations. 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