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Fibroblasts were extracted from the TMJ synovial membrane of four-week-old Japanese white rabbits. The amount of HA and expression levels of HA synthase (HAS) mRNAs induced by TGF-\u03b21 treatment were analyzed by means of high-performance liquid chromatography and real-time polymerase chain-reaction, respectively. Both medium and large amounts of HA were enhanced by the stimulation of TGF-\u03b21. HAS2 mRNA expression was enhanced 13-fold after six-hour stimulation with TGF-\u03b21 (10 ng\/mL), whereas HAS3 mRNA expression was not changed significantly. These results suggest that TGF-\u03b21 enhances the expression of HAS2 mRNA in the TMJ synovial membrane fibroblasts and may contribute to the production of high-molecular-weight HA in the joint fluid.<\/jats:p>","DOI":"10.1177\/154405910408300108","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"40-44","source":"Crossref","is-referenced-by-count":31,"title":["Effects of TGF-\u03b2 on Hyaluronan Anabolism in Fibroblasts Derived from the Synovial Membrane of the Rabbit Temporomandibular Joint"],"prefix":"10.1177","volume":"83","author":[{"given":"K.","family":"Tanimoto","sequence":"first","affiliation":[{"name":"Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ohno","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Doi","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Yoneno","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ohno-Nakahara","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Nakatani","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ueki","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Tanne","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2004,1,1]]},"reference":[{"key":"BALAZS-AND-DENLINGER-1989","doi-asserted-by":"crossref","unstructured":"Balazs EA, Denlinger JL (1989). 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