{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T14:30:20Z","timestamp":1793025020411,"version":"4.5.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2004,2,1]],"date-time":"2004-02-01T00:00:00Z","timestamp":1075593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2004,2]]},"abstract":"<jats:p>Severe periodontitis is associated with elevated inflammatory markers in otherwise healthy populations. However, the nature of this association has not been determined. Our aim was to assess whether the degree of response to periodontal therapy was associated with changes in serological markers of systemic inflammation. Ninety-four systemically healthy subjects with severe generalized periodontitis participated in a prospective six-month blind intervention trial. Periodontal parameters and inflammatory markers [C-reactive Protein (CRP) and Interleukin-6 (IL-6)] were evaluated prior to and 2 and 6 mos after delivery of standard non-surgical periodontal therapy. Six months after treatment, significant reductions in serum IL-6 (p &lt; 0.001, median decrease 0.2 ng\/L, 95% CI 0.1\u20130.4 ng\/L) and CRP (p &lt; 0.0001, median decrease 0.5 mg\/L, 95% CI 0.4\u20130.7) were observed. Decreases in inflammatory markers were significant in subjects with above average clinical response to periodontal therapy after correction for possible confounders. Periodontitis may add to the systemic inflammatory burden of affected individuals.<\/jats:p>","DOI":"10.1177\/154405910408300214","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"156-160","source":"Crossref","is-referenced-by-count":566,"title":["Periodontitis and Systemic Inflammation: Control of the Local Infection                is Associated with a Reduction in Serum Inflammatory Markers"],"prefix":"10.1177","volume":"83","author":[{"given":"F.","family":"D\u2019Aiuto","sequence":"first","affiliation":[{"name":"Department of Periodontology, Eastman Dental Institute and Hospital,\r               University College London, 256 Gray\u2019s Inn Road, London WC1X 8LD, UK;"},{"name":"Eastman Clinical Investigation Center, Eastman Dental Institute and\r               Hospital, University College London; and"},{"name":"Microbiology Unit, Eastman Dental Hospital, University College London\r               Hospitals, NHS Trust;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Parkar","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Eastman Dental Institute and Hospital,\r               University College London, 256 Gray\u2019s Inn Road, London WC1X 8LD, UK;"},{"name":"Eastman Clinical Investigation Center, Eastman Dental Institute and\r               Hospital, University College London; and"},{"name":"Microbiology Unit, Eastman Dental Hospital, University College London\r               Hospitals, NHS Trust;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Andreou","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Eastman Dental Institute and Hospital,\r               University College London, 256 Gray\u2019s Inn Road, London WC1X 8LD, UK;"},{"name":"Eastman Clinical Investigation Center, Eastman Dental Institute and\r               Hospital, University College London; and"},{"name":"Microbiology Unit, Eastman Dental Hospital, University College London\r               Hospitals, NHS Trust;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Suvan","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Eastman Dental Institute and Hospital,\r               University College London, 256 Gray\u2019s Inn Road, London WC1X 8LD, UK;"},{"name":"Eastman Clinical Investigation Center, Eastman Dental Institute and\r               Hospital, University College London; and"},{"name":"Microbiology Unit, Eastman Dental Hospital, University College London\r               Hospitals, NHS Trust;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.M.","family":"Brett","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Eastman Dental Institute and Hospital,\r               University College London, 256 Gray\u2019s Inn Road, London WC1X 8LD, UK;"},{"name":"Eastman Clinical Investigation Center, Eastman Dental Institute and\r               Hospital, University College London; and"},{"name":"Microbiology Unit, Eastman Dental Hospital, University College London\r               Hospitals, NHS Trust;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Ready","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Eastman Dental Institute and Hospital,\r               University College London, 256 Gray\u2019s Inn Road, London WC1X 8LD, UK;"},{"name":"Eastman Clinical Investigation Center, Eastman Dental Institute and\r               Hospital, University College London; 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