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We have localized the eNOS and iNOS by immunohistochemistry and have tested their mRNA expression by RT-PCR and protein levels by Western blots. eNOS is present in the endothelial cells and odontoblasts of the healthy pulp, but an elevation of eNOS mRNA and protein levels with a concomitant dilation of vessels was characteristic under pathological conditions. Healthy pulp tissue failed to exhibit any iNOS; however, acute inflammation enhanced the mRNA and protein levels of iNOS, mainly in the leukocytes. There are differences in localization and expression between eNOS and iNOS in healthy and inflamed dental pulp.<\/jats:p>","DOI":"10.1177\/154405910408300408","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"312-316","source":"Crossref","is-referenced-by-count":77,"title":["Nitric Oxide Synthase in Healthy and Inflamed Human Dental Pulp"],"prefix":"10.1177","volume":"83","author":[{"given":"F.","family":"Di Nardo Di Maio","sequence":"first","affiliation":[{"name":"Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, 78\/A \u00dcll\u00f4i \u00fat, Budapest, Hungary, 1082; and"},{"name":"School of Dentistry, University of Chieti, 1 Via dei Vestini, Chieti, Italy, 66100;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Lohinai","sequence":"additional","affiliation":[{"name":"Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, 78\/A \u00dcll\u00f4i \u00fat, Budapest, Hungary, 1082; and"},{"name":"School of Dentistry, University of Chieti, 1 Via dei Vestini, Chieti, Italy, 66100;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"D\u2019Arcangelo","sequence":"additional","affiliation":[{"name":"Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, 78\/A \u00dcll\u00f4i \u00fat, Budapest, Hungary, 1082; and"},{"name":"School of Dentistry, University of Chieti, 1 Via dei Vestini, Chieti, Italy, 66100;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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