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It was expected that saliva may contain high concentrations of adrenomedullin, which has antimicrobial activity in vitro, which may have functional implications in the oral cavity. Saliva from the submandibular and parotid glands contained higher concentrations of adrenomedullin than did the circulation, but lower concentrations than in whole saliva. This suggests that oral epithelium may contribute the majority of the adrenomedullin peptide found in saliva. Specific adrenomedullin receptors were found in cell lines from the submandibular (HSG) and parotid (HSY) salivary glands. These findings suggest a paracrine\/autocrine role for adrenomedullin in these tissues; however, the concentration of adrenomedullin in saliva was insufficient to suggest a significant antimicrobial action in the healthy oral cavity.<\/jats:p>","DOI":"10.1177\/154405910408300412","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"333-337","source":"Crossref","is-referenced-by-count":21,"title":["Expression of Adrenomedullin and its Receptors in Human Salivary Tissue"],"prefix":"10.1177","volume":"83","author":[{"given":"S.","family":"Kapas","sequence":"first","affiliation":[{"name":"Molecular Signalling Group, Clinical Sciences Research Centre, and"},{"name":"Department of Endocrinology, Barts & the London, Queen Mary\u2019s School of Medicine & Dentistry, Suite 12, Dominion House, Bartholomew Close, London EC1A 7BE, UK;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Pahal","sequence":"additional","affiliation":[{"name":"Molecular Signalling Group, Clinical Sciences Research Centre, and"},{"name":"Department of Endocrinology, Barts & the London, Queen Mary\u2019s School of Medicine & Dentistry, Suite 12, Dominion House, Bartholomew Close, London EC1A 7BE, UK;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.T.","family":"Cruchley","sequence":"additional","affiliation":[{"name":"Molecular Signalling Group, Clinical Sciences Research Centre, and"},{"name":"Department of Endocrinology, Barts & the London, Queen Mary\u2019s School of Medicine & Dentistry, Suite 12, Dominion House, Bartholomew Close, London EC1A 7BE, UK;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Hagi-Pavli","sequence":"additional","affiliation":[{"name":"Molecular Signalling Group, Clinical Sciences Research Centre, and"},{"name":"Department of Endocrinology, Barts & the London, Queen Mary\u2019s School of Medicine & Dentistry, Suite 12, Dominion House, Bartholomew Close, London EC1A 7BE, UK;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.P.","family":"Hinson","sequence":"additional","affiliation":[{"name":"Molecular Signalling Group, Clinical Sciences Research Centre, and"},{"name":"Department of Endocrinology, Barts & the London, Queen Mary\u2019s School of Medicine & Dentistry, Suite 12, Dominion House, Bartholomew Close, London EC1A 7BE, UK;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2004,4,1]]},"reference":[{"key":"ALLAKER-AND-KAPAS-2003","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(03)00033-8"},{"key":"ALLAKER-ETAL-1999","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.1999.tb01250.x"},{"key":"CAMERON-AND-FLEMING-1998","doi-asserted-by":"publisher","DOI":"10.1210\/endo.139.5.5965"},{"key":"CARON-AND-SMITHIES-2001","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.2.615"},{"key":"CARON-AND-SMITHIES-2002","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.10046"},{"key":"CHU-ETAL-2001","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(01)00509-5"},{"key":"HINSON-ETAL-2000","doi-asserted-by":"crossref","unstructured":"Hinson JP, Kapas S, Smith DM -2000- Adrenomedullin, a multifunctional regulatory peptide. 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