{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T12:20:39Z","timestamp":1777810839691,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2004,5,1]],"date-time":"2004-05-01T00:00:00Z","timestamp":1083369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:p>Recently, mast cells have been shown to produce cytokines which can direct the development of T-cell subsets. The aim of the present study was to determine the relationship between mast cells and the Th1\/Th2 response in human periodontal disease. Tryptase+ mast cell numbers were decreased in chronic periodontitis tissues compared with healthy\/gingivitis lesions. Lower numbers of c-kit+ cells, which remained constant regardless of clinical status, indicate that there may be no increased migration of mast cells into periodontal disease lesions. While there were no differences in IgG2+ or IgG4+ cell numbers in healthy\/gingivitis samples, there was an increase in IgG4+ cells compared with IgG2+ cells in periodontitis lesions, numbers increasing with disease severity. This suggests a predominance of Th2 cells in periodontitis, although mast cells may not be the source of Th2-inducing cytokines.<\/jats:p>","DOI":"10.1177\/154405910408300506","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"384-387","source":"Crossref","is-referenced-by-count":32,"title":["Mast Cells in Human Periodontal Disease"],"prefix":"10.1177","volume":"83","author":[{"given":"E.","family":"Gemmell","sequence":"first","affiliation":[{"name":"Oral Biology and Pathology, School of Dentistry, The University of Queensland, Brisbane 4072, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.L.","family":"Carter","sequence":"additional","affiliation":[{"name":"Oral Biology and Pathology, School of Dentistry, The University of Queensland, Brisbane 4072, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.J.","family":"Seymour","sequence":"additional","affiliation":[{"name":"Oral Biology and Pathology, School of Dentistry, The University of Queensland, Brisbane 4072, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2004,5,1]]},"reference":[{"key":"AGRESTI-AND-VERCELLI-2002","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-5890(01)00121-3"},{"key":"CHAN-ETAL-1991","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.4.869"},{"key":"FOX-ETAL-1994","doi-asserted-by":"publisher","DOI":"10.1006\/cimm.1994.1272"},{"key":"FRANDJI-ETAL-1996","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830261036"},{"key":"GALLI-ETAL-1995","doi-asserted-by":"publisher","DOI":"10.1159\/000236928"},{"key":"GEMMELL-AND-SEYMOUR-1995","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1995.66.9.780"},{"key":"GEMMELL-ETAL-2002","doi-asserted-by":"publisher","DOI":"10.1177\/154411130201300104"},{"key":"GEMMELL-ETAL-2003","doi-asserted-by":"publisher","DOI":"10.1046\/j.0902-0055.2002.00098.x"},{"key":"GURISH-AND-BOYCE-2002","doi-asserted-by":"publisher","DOI":"10.1385\/CRIAI:22:2:107"},{"key":"IRANI-AND-SCHWARTZ-1989","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1989.tb02357.x"},{"key":"IRANI-ETAL-1986","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.12.4464"},{"key":"MALAVIYA-ETAL-1996","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.156.4.1490"},{"key":"MARIETTA-ETAL-1996","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830260108"},{"key":"MECHERI-AND-DAVID-1997","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(97)01034-7"},{"key":"MEKORI-AND-METCALFE-1999","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70316-7"},{"key":"PLAUT-ETAL-1989","doi-asserted-by":"publisher","DOI":"10.1038\/339064a0"},{"key":"REINHARDT-ETAL-1988","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1988.59.10.656"},{"key":"SEYMOUR-ETAL-1983","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1983.54.9.522"},{"key":"SHANAS-ETAL-1998","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(98)00137-4"},{"key":"SMITH-ETAL-1994","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830240408"},{"key":"TANAKA-ETAL-2003","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.6.771"},{"key":"WASSERMAN-1994","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/150.5_Pt_2.S39"}],"container-title":["Journal of Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/154405910408300506","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/154405910408300506","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/154405910408300506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:01:02Z","timestamp":1777496462000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/154405910408300506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["10.1177\/154405910408300506"],"URL":"https:\/\/doi.org\/10.1177\/154405910408300506","relation":{},"ISSN":["0022-0345","1544-0591"],"issn-type":[{"value":"0022-0345","type":"print"},{"value":"1544-0591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,5]]}}}