{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:14:49Z","timestamp":1787019289291,"version":"build-2736575974"},"reference-count":30,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:p>Previously, we discovered that RANKL expression is induced in compressed periodontal ligament cells, and that this promotes osteoclastogenesis on the compression side in orthodontic tooth movement. We hypothesized that local OPG gene transfer to the periodontium would neutralize the RANKL activity induced by mechanical compressive force, thereby inhibiting osteoclastogenesis and diminishing tooth movement. The upper first molars of six-week-old male Wistar rats were moved palatally by means of a fixed-orthodontic wire. A mouse OPG expression plasmid [pcDNA3.1(+)-mOPG] was constructed, and the production of functional OPG protein was confirmed in vitro. The inactivated HVJ envelope vector containing pcDNA3.1(+)-mOPG or PBS was injected periodically into the palatal periodontal tissue of upper first molars. When this local OPG gene transfer was performed, OPG production was induced, and osteoclastogenesis was inhibited. Local OPG gene transfer significantly diminished tooth movement. In this study, we report that OPG gene transfer to periodontal tissue inhibited RANKL-mediated osteoclastogenesis and inhibited experimental tooth movement.<\/jats:p>","DOI":"10.1177\/154405910408301206","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"920-925","source":"Crossref","is-referenced-by-count":138,"title":["Local OPG Gene Transfer to Periodontal Tissue Inhibits Orthodontic Tooth Movement"],"prefix":"10.1177","volume":"83","author":[{"given":"H.","family":"Kanzaki","sequence":"first","affiliation":[{"name":"Division of Orthodontics and Dentofacial Orthopedics, and Division of Oral Dysfunction Science, Department of Oral Health and Development Sciences, Graduate School of Dentistry, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Chiba","sequence":"additional","affiliation":[{"name":"Division of Orthodontics and Dentofacial Orthopedics, and Division of Oral Dysfunction Science, Department of Oral Health and Development Sciences, Graduate School of Dentistry, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Division of Orthodontics and Dentofacial Orthopedics, and Division of Oral Dysfunction Science, Department of Oral Health and Development Sciences, Graduate School of Dentistry, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Haruyama","sequence":"additional","affiliation":[{"name":"Division of Orthodontics and Dentofacial Orthopedics, and Division of Oral Dysfunction Science, Department of Oral Health and Development Sciences, Graduate School of Dentistry, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Division of Orthodontics and Dentofacial Orthopedics, and Division of Oral Dysfunction Science, Department of Oral Health and Development Sciences, Graduate School of Dentistry, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Mitani","sequence":"additional","affiliation":[{"name":"Division of Orthodontics and Dentofacial Orthopedics, and Division of Oral Dysfunction Science, Department of Oral Health and Development Sciences, Graduate School of Dentistry, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2004,12,1]]},"reference":[{"key":"ADACHI-ETAL-1994","doi-asserted-by":"publisher","DOI":"10.1177\/00220345940730081301"},{"key":"ALHASHIMI-ETAL-2001","doi-asserted-by":"publisher","DOI":"10.1067\/mod.2001.110809"},{"key":"BLESING-AND-KERR-1996","doi-asserted-by":"publisher","DOI":"10.3109\/10611869608996825"},{"key":"BRUDVIK-AND-RYGH-1994","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/16.4.265"},{"key":"CHUMBLEY-AND-TUNCAY-1986","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9416(86)90053-9"},{"key":"COLLINS-AND-SINCLAIR-1988","doi-asserted-by":"publisher","DOI":"10.1016\/0889-5406(88)90052-2"},{"key":"DAVIDOVITCH-1988","doi-asserted-by":"publisher","DOI":"10.1016\/S0011-8532(22)00320-2"},{"key":"HASHIMOTO-ETAL-2001","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/23.5.535"},{"key":"IGARASHI-ETAL-1994","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-5406(94)70048-6"},{"key":"IWASAKI-ETAL-2001","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(00)00088-1"},{"key":"KAKU-ETAL-2001","doi-asserted-by":"publisher","DOI":"10.1177\/00220345010800100401"},{"key":"KANEDA-ETAL-2002","doi-asserted-by":"publisher","DOI":"10.1006\/mthe.2002.0647"},{"key":"KANZAKI-ETAL-2002","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2002.17.2.210"},{"key":"KEHOE-ETAL-1996","unstructured":"Kehoe MJ, Cohen SM, Zarrinnia K, Cowan A -1996- The effect of acetaminophen, ibuprofen, and misoprostol on prostaglandin E\n                      2\n                      synthesis and the degree and rate of orthodontic tooth movement, Angle Orthod 66:339\u2013349."},{"key":"KIM-ETAL-1999","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-5406(99)70290-8"},{"key":"KOHNO-ETAL-2003","doi-asserted-by":"publisher","DOI":"10.1177\/154405910308200306"},{"key":"LEE-1990","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-5406(05)81600-2"},{"key":"LOSSDORFER-ETAL-2002","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.2002.1970"},{"key":"LOWNEY-ETAL-1995","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-5406(95)70052-8"},{"key":"OSHIRO-ETAL-2002","doi-asserted-by":"publisher","DOI":"10.1002\/ar.10061"},{"key":"ROBERTS-ETAL-1981","doi-asserted-by":"publisher","DOI":"10.1016\/S0011-8532(22)02820-8"},{"key":"ROCHE-ETAL-1997","unstructured":"Roche JJ, Cisneros GJ, Acs G -1997- The effect of acetaminophen on tooth movement in rabbits. Angle Orthod 67:231\u2013236."},{"key":"SAITO-ETAL-1991","doi-asserted-by":"publisher","DOI":"10.1016\/0889-5406(91)70005-H"},{"key":"SAITOH-ETAL-2000","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0185(20001201)260:4<392::AID-AR90>3.0.CO;2-O"},{"key":"SCHEVEN-ETAL-1986","doi-asserted-by":"publisher","DOI":"10.1038\/321079a0"},{"key":"SIMONET-ETAL-1997","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80209-3"},{"key":"SOMA-ETAL-2000","doi-asserted-by":"publisher","DOI":"10.1177\/00220345000790091301"},{"key":"STOREY-1973","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9416(73)90353-9"},{"key":"UDAGAWA-ETAL-1999","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(99)00210-0"},{"key":"YASUDA-ETAL-1999","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(99)00121-0"}],"container-title":["Journal of Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/154405910408301206","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/154405910408301206","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/154405910408301206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:00:39Z","timestamp":1777496439000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/154405910408301206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12]]},"references-count":30,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["10.1177\/154405910408301206"],"URL":"https:\/\/doi.org\/10.1177\/154405910408301206","relation":{},"ISSN":["0022-0345","1544-0591"],"issn-type":[{"value":"0022-0345","type":"print"},{"value":"1544-0591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12]]}}}