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In this study, we investigated changes in masseter muscle spindle function under an increased OVD (iOVD) condition. Responses of primary and secondary endings of masseter muscle spindles to cyclic sinusoidal stretches were investigated. Twenty barbiturate-anesthetized female Wistar rats were divided into control and iOVD groups. Rats in the iOVD group received a 2.0-mm composite resin build-up to the maxillary molars. After iOVD, masseter muscle spindle sensitivity gradually decreased. Primary and secondary spindle endings were affected differently. We conclude that iOVD caused reduction in masseter muscle spindle sensitivity. This result suggests that peripheral sensory plasticity may occur following changes in OVD. Such changes may provide a basis for physiological adaptation to clinical occlusal adjustments.<\/jats:p>","DOI":"10.1177\/154405910508400307","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"245-249","source":"Crossref","is-referenced-by-count":27,"title":["Role of Occlusal Vertical Dimension in Spindle Function"],"prefix":"10.1177","volume":"84","author":[{"given":"T.","family":"Yabushita","sequence":"first","affiliation":[{"name":"Orthodontic Science, Department of Orofacial Development and Function, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549; and"},{"name":"Division of Integrative Sensory Physiology, Department of Developmental and Reconstructive Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8588, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.L.","family":"Zeredo","sequence":"additional","affiliation":[{"name":"Orthodontic Science, Department of Orofacial Development and Function, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549; and"},{"name":"Division of Integrative Sensory Physiology, Department of Developmental and Reconstructive Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8588, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Toda","sequence":"additional","affiliation":[{"name":"Orthodontic Science, Department of Orofacial Development and Function, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549; and"},{"name":"Division of Integrative Sensory Physiology, Department of Developmental and Reconstructive Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8588, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Soma","sequence":"additional","affiliation":[{"name":"Orthodontic Science, Department of Orofacial Development and Function, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549; and"},{"name":"Division of Integrative Sensory Physiology, Department of Developmental and Reconstructive Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8588, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2005,3,1]]},"reference":[{"key":"AHN-AND-SCHNEIDER-2000","doi-asserted-by":"publisher","DOI":"10.1067\/mod.2000.109312"},{"key":"AKAGAWA-ETAL-1983","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3913(83)90216-0"},{"key":"BRILL-AND-TRYDE-1974","doi-asserted-by":"publisher","DOI":"10.1159\/000392723"},{"key":"BROEKHUIJSEN-AND-VAN-WILLIGEN-1983","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(83)90133-4"},{"key":"CARLSON-AND-SCHNEIDERMAN-1983","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(83)90011-0"},{"key":"CARLSSON-ETAL-1979","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3913(79)90008-8"},{"key":"CHENEY-AND-PRESTON-1976","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1976.39.1.1"},{"key":"CHRISTENSEN-1970","unstructured":"Christensen J (1970). 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