{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:34:19Z","timestamp":1792460059246,"version":"4.5.0"},"reference-count":18,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:p>The dental follicle regulates the alveolar bone resorption needed for tooth eruption. In the rat first mandibular molar, a decrease in the expression of osteoprotegerin (OPG) in the dental follicle at day 3 enables the osteoclastogenesis needed for eruption to occur. Because colony-stimulating factor-1 (CSF-1) is maximally expressed in the dental follicle at day 3, it was hypothesized that CSF-1 down-regulates OPG gene expression in the dental follicle in vivo. To test this, we compared the expression of OPG in osteopetrotic toothless ( tl\/tl) rats deficient in CSF-1 with expression in their normal littermates for given ages. OPG gene expression was found to be higher in the dental follicle of the tl\/tl mutants than in normals. Transfecting short interfering RNA specific for CSF-1 mRNA into dental follicle cells resulted in an up-regulation of OPG expression. Thus, these studies support our hypothesis that the down-regulation of OPG needed for tooth eruption is mediated by CSF-1.<\/jats:p>","DOI":"10.1177\/154405910508400911","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"837-841","source":"Crossref","is-referenced-by-count":57,"title":["CSF-1 Regulation of Osteoclastogenesis for Tooth Eruption"],"prefix":"10.1177","volume":"84","author":[{"given":"G.E.","family":"Wise","sequence":"first","affiliation":[{"name":"Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA; and"},{"name":"Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA; and"},{"name":"Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.R.","family":"Odgren","sequence":"additional","affiliation":[{"name":"Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA; and"},{"name":"Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA; and"},{"name":"Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2005,9,1]]},"reference":[{"key":"ARAI-ETAL-1999","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.12.1741"},{"key":"CIELINSKI-ETAL-1994","unstructured":"Cielinski MJ, Jolie M, Wise GE, Ando DG, Marks SC Jr -1994- Colony-stimulating factor-1 -CSF-1- is a potent stimulator of tooth eruption in the rat. 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