{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:14:49Z","timestamp":1787019289161,"version":"build-2736575974"},"reference-count":28,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:p>Patients with localized aggressive periodontitis have type-1 cytokines in gingival crevicular fluid and high titers of IFN-\u03b3-dependent IgG2 reactive with P. gingivalis in gingival crevicular fluid and serum. Localized aggressive periodontitis monocytes spontaneously differentiate into dendritic cells that can stimulate IFN-\u03b3 production by NK cells. These relationships prompted the hypothesis that P. gingivalis-dendritic cell-NK cell interactions might promote type-1 cytokine responses. Although P. gingivalis is not a potent inducer of Th1 responses, it stimulated strong IL-12 responses by monocyte-derived dendritic cells in the presence of IFN-\u03b3, and IFN-\u03b3 was produced by NK cells within 24 hrs in the presence of dendritic cells. Anti- P. gingivalis IgG2 responses were enhanced by dendritic cells, and removal of NK cells reduced IFN-\u03b3- and P. gingivalis-specific IgG2. Thus, P. gingivalis-dendritic cell-NK cell interactions apparently resulted in reciprocal stimulation and increased type-1 cytokine production by both dendritic cells and NK cells, and increased P. gingivalis-specific IgG2.<\/jats:p>","DOI":"10.1177\/154405910508400915","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"858-862","source":"Crossref","is-referenced-by-count":35,"title":["Dendritic-NK Cell Interactions in\n                    <i>P. gingivalis<\/i>\n                    -specific Responses"],"prefix":"10.1177","volume":"84","author":[{"given":"T.","family":"Kikuchi","sequence":"first","affiliation":[{"name":"Clinical Research Center for Periodontal Diseases, School of Dentistry, VCU, PO Box 980556, Richmond, VA 23298-0556, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.L.","family":"Willis","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Periodontal Diseases, School of Dentistry, VCU, PO Box 980556, Richmond, VA 23298-0556, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Liu","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Periodontal Diseases, School of Dentistry, VCU, PO Box 980556, Richmond, VA 23298-0556, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.B.","family":"Purkall","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Periodontal Diseases, School of Dentistry, VCU, PO Box 980556, Richmond, VA 23298-0556, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Sukumar","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Periodontal Diseases, School of Dentistry, VCU, PO Box 980556, Richmond, VA 23298-0556, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.E.","family":"Barbour","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Periodontal Diseases, School of Dentistry, VCU, PO Box 980556, Richmond, VA 23298-0556, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.A.","family":"Schenkein","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Periodontal Diseases, School of Dentistry, VCU, PO Box 980556, Richmond, VA 23298-0556, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.G.","family":"Tew","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Periodontal Diseases, School of Dentistry, VCU, PO Box 980556, Richmond, VA 23298-0556, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2005,9,1]]},"reference":[{"key":"AGOSTINI-ETAL-2001","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.1094"},{"key":"BAINBRIDGE-AND-DARVEAU-2001","doi-asserted-by":"publisher","DOI":"10.1080\/000163501750266710"},{"key":"BARBOUR-ETAL-2002","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.6.2780-2786.2002"},{"key":"BRANDTZAEG-2001","doi-asserted-by":"publisher","DOI":"10.1080\/00016350152509265"},{"key":"CALIFANO-ETAL-1997","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1997.68.8.734"},{"key":"CALIFANO-ETAL-1999","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.7.730"},{"key":"CHOI-ETAL-2001","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-302X.2001.160604.x"},{"key":"CIRRINCIONE-ETAL-2002","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.1.45"},{"key":"COOPER-ETAL-2004","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2003.10.012"},{"key":"FERLAZZO-AND-MUNZ-2004","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.3.1333"},{"key":"GUNSOLLEY-ETAL-1987","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1987.58.5.314"},{"key":"HAFFAJEE-AND-SOCRANSKY-1994","doi-asserted-by":"crossref","unstructured":"Haffajee AD, Socransky SS -1994- Microbial etiological agents of destructive periodontal diseases. 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