{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:04:28Z","timestamp":1790276668379,"version":"4.1.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:p>There is strong evidence that genetic as well as environmental factors affect the development of periodontitis, and some suggestion that aggressive and chronic forms of the disease share the same genetic predisposition. This study addresses the hypothesis that there are both shared and unique genetic associations in these forms of periodontitis. A sample of 51 patients with aggressive disease, 57 patients with chronic disease, and 100 healthy controls was recruited for this study. Ten functional polymorphisms in 7 candidate genes were genotyped. The results show statistically significant (p \u2264 0.05) differences between genotype frequencies in aggressive and controls (IL-1B +3954 &amp; IL-6 \u2212174); chronic and controls (IL-6 \u2212174 &amp; VDR \u22121056); chronic and aggressive periodontitis (IL-1A \u2212889); and periodontitis as a whole and controls (VDR \u22121056, TLR-4 399 &amp; IL-6 \u2212174). These results suggest that there are in fact both shared and unique genetic associations in aggressive and chronic periodontitis.<\/jats:p>","DOI":"10.1177\/154405910508401211","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"1149-1153","source":"Crossref","is-referenced-by-count":171,"title":["Functional Gene Polymorphisms in Aggressive and Chronic Periodontitis"],"prefix":"10.1177","volume":"84","author":[{"given":"P.M.","family":"Brett","sequence":"first","affiliation":[{"name":"Department of Periodontology, Eastman Dental Institute, University College London, 256 Gray\u2019s Inn Road, London WC1X 8LD, UK;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Zygogianni","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Eastman Dental Institute, University College London, 256 Gray\u2019s Inn Road, London WC1X 8LD, UK;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.S.","family":"Griffiths","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Eastman Dental Institute, University College London, 256 Gray\u2019s Inn Road, London WC1X 8LD, UK;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Tomaz","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Eastman Dental Institute, University College London, 256 Gray\u2019s Inn Road, London WC1X 8LD, UK;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Parkar","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Eastman Dental Institute, University College London, 256 Gray\u2019s Inn Road, London WC1X 8LD, UK;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"D\u2019Aiuto","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Eastman Dental Institute, University College London, 256 Gray\u2019s Inn Road, London WC1X 8LD, UK;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Tonetti","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Eastman Dental Institute, University College London, 256 Gray\u2019s Inn Road, London WC1X 8LD, UK;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2005,12,1]]},"reference":[{"key":"AITHAL-ETAL-2001","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010604307776"},{"key":"ALBANDAR-ETAL-1997","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1997.68.6.545"},{"key":"ARMITAGE-1999","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"BEATY-ETAL-1987","unstructured":"Beaty TH, Boughman JA, Yang P, Astemborski JA, Suzuki JB -1987- Genetic analysis of juvenile periodontitis in families ascertained through an affected proband. Am J Hum Genet 40:443\u2013452."},{"key":"BLAND-AND-ALTMAN-2000","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7247.1468"},{"key":"COREY-ETAL-1993","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.12.1205"},{"key":"DI-GIOVINE-ETAL-1992","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/1.6.450"},{"key":"FERNANDEZ-REAL-ETAL-2001","doi-asserted-by":"crossref","unstructured":"Fernandez-Real JM, Vendrell J, Richart C, Gutierrez C, Ricart W -2001- Platelet count and interleukin 6 gene polymorphism in healthy subjects. BMC Med Genet 2:6.","DOI":"10.1186\/1471-2350-2-6"},{"key":"HENNIG-ETAL-1999","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.9.1032"},{"key":"INAGAKI-ETAL-2003","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.2.161"},{"key":"KELLY-ETAL-2000","unstructured":"Kelly M, Steele J, Nutall N, Bradnock G, Morris J, Pine C,\n                      et al.\n                      -2000- In: Adult dental health survey 1998\u2014Oral health in the United Kingdom. Walker A, Cooper I, editors. London: HMSO, pp. 123\u2013146."},{"key":"KINANE-ETAL-1999","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1999.tb02270.x"},{"key":"KORNMAN-ETAL-1997","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb01187.x"},{"key":"LANG-ETAL-2000","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2000.035002102.x"},{"key":"LORENZ-ETAL-2001","doi-asserted-by":"publisher","DOI":"10.2144\/01311bm01"},{"key":"MARAZITA-ETAL-1994","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1994.65.6.623"},{"key":"MCDEVITT-ETAL-2000","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.2.156"},{"key":"MCDOWELL-ETAL-1995","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380210"},{"key":"MCGUIRE-AND-NUNN-1999","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.1.49"},{"key":"MICHALOWICZ-ETAL-1991","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1991.62.5.293"},{"key":"MORRISON-1998","unstructured":"Morrison N -1998- Vitamin D receptor gene variants and osteoporosis: a contributor to a polygenic control of bone density. In: Vitamin D. Feldman D, Glorieux FH, Pike JW, editors. San Diego: Academic Press, pp. 713\u2013732."},{"key":"POCIOT-ETAL-1992","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1992.tb01480.x"},{"key":"PURCELL-ETAL-2003","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/19.1.149"},{"key":"SHIRODARIA-ETAL-2000","doi-asserted-by":"publisher","DOI":"10.1177\/00220345000790110801"},{"key":"SUZUKI-ETAL-2004","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.03.126"},{"key":"TONETTI-AND-MOMBELLI-1999","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.39"},{"key":"YAMAZAKI-ETAL-2001","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2001.028009828.x"}],"container-title":["Journal of Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/154405910508401211","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/154405910508401211","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/154405910508401211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:01:37Z","timestamp":1777496497000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/154405910508401211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12]]},"references-count":27,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["10.1177\/154405910508401211"],"URL":"https:\/\/doi.org\/10.1177\/154405910508401211","relation":{},"ISSN":["0022-0345","1544-0591"],"issn-type":[{"value":"0022-0345","type":"print"},{"value":"1544-0591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,12]]}}}