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Orchiectomized male BALB\/c mice were treated with placebo- or testosterone-containing hormone pellets for 14 days. Glands were collected, and total RNA was isolated. Samples were analyzed for differentially expressed mRNAs by CodeLink microarrays, and the data were evaluated with GeneSifter. Androgens significantly (p &lt; 0.05) influenced the expression of over 1300 genes, and many (n = 366) of the genes differentially regulated by androgen treatment were also differentially expressed in males compared with the females in our previous study. These findings support our hypotheses that testosterone extensively influences gene expression in the male submandibular gland, and that many of the sex differences are due to androgens.<\/jats:p>","DOI":"10.1177\/154405910508401218","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"1187-1192","source":"Crossref","is-referenced-by-count":23,"title":["Influence of Androgens on Gene Expression in the BALB\/c Mouse Submandibular Gland"],"prefix":"10.1177","volume":"84","author":[{"given":"N.S.","family":"Treister","sequence":"first","affiliation":[{"name":"Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, MA, USA;"},{"name":"Schepens Eye Research Institute, Boston, MA, USA;"},{"name":"Department of Ophthalmology, Harvard Medical School, Boston, MA, USA; and"},{"name":"Department of Physics, University of Massachusetts-Boston, Boston, MA, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.M.","family":"Richards","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, MA, USA;"},{"name":"Schepens Eye Research Institute, Boston, MA, USA;"},{"name":"Department of Ophthalmology, Harvard Medical School, Boston, MA, USA; and"},{"name":"Department of Physics, University of Massachusetts-Boston, Boston, MA, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, MA, USA;"},{"name":"Schepens Eye Research Institute, Boston, MA, USA;"},{"name":"Department of Ophthalmology, Harvard Medical School, Boston, MA, USA; and"},{"name":"Department of Physics, University of Massachusetts-Boston, Boston, MA, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.V.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, MA, USA;"},{"name":"Schepens Eye Research Institute, Boston, MA, USA;"},{"name":"Department of Ophthalmology, Harvard Medical School, Boston, MA, USA; and"},{"name":"Department of Physics, University of Massachusetts-Boston, Boston, MA, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.A.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, MA, USA;"},{"name":"Schepens Eye Research Institute, Boston, MA, USA;"},{"name":"Department of Ophthalmology, Harvard Medical School, Boston, MA, USA; and"},{"name":"Department of Physics, University of Massachusetts-Boston, Boston, MA, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2005,12,1]]},"reference":[{"key":"ARIGA-ETAL-1989","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(89)90011-1"},{"key":"ASHBURNER-ETAL-2000","doi-asserted-by":"publisher","DOI":"10.1038\/75556"},{"key":"BJORLING-ETAL-2002","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00568-1"},{"key":"CANGUSSU-ETAL-2002","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.10041"},{"key":"CERBON-ETAL-1996","doi-asserted-by":"crossref","unstructured":"Cerbon MA, Camacho-Arroyo I, Gamboa-Dominguez A, Gonzalez-Mariscal G -1996- The rabbit submandibular gland: sexual dimorphism, effects of gonadectomy, and variations across the female reproductive cycle. 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