{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T12:27:27Z","timestamp":1777811247463,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:p>Activated matrix metalloproteinase-3 (MMP-3) can contribute to periodontal ligament destruction in adult periodontitis. Since MMP-3 has been reported to activate proMMP-8 and -9, it was speculated that gingival tissue fibroblast-derived MMP-3 might, in periodontitis, be responsible for activation of gingival crevicular fluid (GCF) neutrophil-derived proMMP-8 and -9. Immunohistochemistry disclosed MMP-3 in gingival fibroblasts in periodontitis. Cultured gingival fibroblasts released only pro-MMP-3 when stimulated with tumor necrosis factor-\u03b1. However, Western blot revealed partially activated MMP-3, MMP-8, and MMP-9 in periodontitis GCF. Active MMP-8 (p &lt; 0.05) and MMP-9 (p &lt; 0.05) correlated with the presence of active MMP-3. It seems that resident gingival fibroblasts produce pro-MMP-3 in GCF, where it becomes activated, probably by cathepsin G or elastase released by neutrophils. Active MMP-3 then activates neutrophil-derived pro-MMP-8 and -9. Different tissue compartments\/cells exert co-operative actions in mutual local MMP activation cascades.<\/jats:p>","DOI":"10.1177\/154405910608500110","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"59-63","source":"Crossref","is-referenced-by-count":43,"title":["Gingival Tissue and Crevicular Fluid Co-operation in Adult Periodontitis"],"prefix":"10.1177","volume":"85","author":[{"given":"A.","family":"Beklen","sequence":"first","affiliation":[{"name":"Department of Medicine\/Inv\u00e4rtes medicin, Helsinki University Hospital, Biomedicum Helsinki, PO Box 700 -Haartmaninkatu 8-, FIN-00029 HUS, Helsinki, Finland;"},{"name":"Institute of Biomedicine\/Anatomy, University of Helsinki, Helsinki, Finland;"},{"name":"Medico-social, Dental Clinic, Bogazici University, Istanbul, Turkey;"},{"name":"Department of Oral and Maxillofacial Diseases, HUCH, Institute of Dentistry, University of Helsinki, Box 41 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Medicine\/Inv\u00e4rtes medicin, Helsinki University Hospital, Biomedicum Helsinki, PO Box 700 -Haartmaninkatu 8-, FIN-00029 HUS, Helsinki, Finland;"},{"name":"Institute of Biomedicine\/Anatomy, University of Helsinki, Helsinki, Finland;"},{"name":"Medico-social, Dental Clinic, Bogazici University, Istanbul, Turkey;"},{"name":"Department of Oral and Maxillofacial Diseases, HUCH, Institute of Dentistry, University of Helsinki, Box 41 FIN-00014 Helsinki, Finland;"},{"name":"University of Gazi, Faculty of Dentistry, Department of Periodontology, Ankara, Turkey;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Hanemaaijer","sequence":"additional","affiliation":[{"name":"Department of Medicine\/Inv\u00e4rtes medicin, Helsinki University Hospital, Biomedicum Helsinki, PO Box 700 -Haartmaninkatu 8-, FIN-00029 HUS, Helsinki, Finland;"},{"name":"Institute of Biomedicine\/Anatomy, University of Helsinki, Helsinki, Finland;"},{"name":"Medico-social, Dental Clinic, 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