{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T12:29:27Z","timestamp":1777811367288,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:p>\n                    \u03b1\n                    <jats:sub>1<\/jats:sub>\n                    -Adrenoceptor has been discovered to exist in many human tissues and mediates important physiological functions. The purpose of this study was to detect the expression, distribution, and function of \u03b1\n                    <jats:sub>1<\/jats:sub>\n                    -adrenoceptor subtypes in human submandibular glands. \u03b1\n                    <jats:sub>1A<\/jats:sub>\n                    - and \u03b1\n                    <jats:sub>1B<\/jats:sub>\n                    -Adrenoceptor mRNAs were identified by reverse-transcription\/polymerase chain-reaction (RT-PCR), and their proteins were detected by Western blotting. No expression of the \u03b1\n                    <jats:sub>1D<\/jats:sub>\n                    -adrenoceptor mRNA and protein was found. By in situ hybridization and immunohistochemistry, \u03b1\n                    <jats:sub>1A<\/jats:sub>\n                    - and \u03b1\n                    <jats:sub>1B<\/jats:sub>\n                    -adrenoceptor mRNAs and proteins were shown to be widespread in both ductal and acinar cells. By confocal microscopy, phenylephrine (stimulating both \u03b1\n                    <jats:sub>1A<\/jats:sub>\n                    - and \u03b1\n                    <jats:sub>1B<\/jats:sub>\n                    -adrenoceptors) or A61603 (\u03b1\n                    <jats:sub>1A<\/jats:sub>\n                    -selective agonist) induced an increase in intracellular calcium by 2.33 \u00b1 0.18-fold and 1.81 \u00b1 0.43-fold, respectively, while 5-methylurapidil (\u03b1\n                    <jats:sub>1A<\/jats:sub>\n                    -selective antagonist) partly blocked calcium mobility stimulated by phenylephrine. The results indicated that functional \u03b1\n                    <jats:sub>1A<\/jats:sub>\n                    - and \u03b1\n                    <jats:sub>1B<\/jats:sub>\n                    -adrenoceptors were expressed in human submandibular glands, and might contribute to the regulation of saliva synthesis and secretion.\n                  <\/jats:p>","DOI":"10.1177\/154405910608500309","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"251-256","source":"Crossref","is-referenced-by-count":7,"title":["Functional \u03b1\n                    <sub>1<\/sub>\n                    -Adrenoceptor Subtypes in Human Submandibular Glands"],"prefix":"10.1177","volume":"85","author":[{"given":"Z.","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and"},{"name":"Department of Oral Pathology, Peking University School and Hospital of Stomatology, Zhong Guan Cun South St. 22, 100081 Beijing, PRC;"},{"name":"Department of Pathophysiology, Peking University Health Science Center; and"},{"name":"Institute of Vascular Medicine, Peking University Third Hospital, Beijing, PRC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.L.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and"},{"name":"Department of Oral Pathology, Peking University School and Hospital of Stomatology, Zhong Guan Cun South St. 22, 100081 Beijing, PRC;"},{"name":"Department of Pathophysiology, Peking University Health Science Center; and"},{"name":"Institute of Vascular Medicine, Peking University Third Hospital, Beijing, PRC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.Y.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and"},{"name":"Department of Oral Pathology, Peking University School and Hospital of Stomatology, Zhong Guan Cun South St. 22, 100081 Beijing, PRC;"},{"name":"Department of Pathophysiology, Peking University Health Science Center; and"},{"name":"Institute of Vascular Medicine, Peking University Third Hospital, Beijing, PRC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and"},{"name":"Department of Oral Pathology, Peking University School and Hospital of Stomatology, Zhong Guan Cun South St. 22, 100081 Beijing, PRC;"},{"name":"Department of Pathophysiology, Peking University Health Science Center; and"},{"name":"Institute of Vascular Medicine, Peking University Third Hospital, Beijing, PRC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.Y.","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and"},{"name":"Department of Oral Pathology, Peking University School and Hospital of Stomatology, Zhong Guan Cun South St. 22, 100081 Beijing, PRC;"},{"name":"Department of Pathophysiology, Peking University Health Science Center; and"},{"name":"Institute of Vascular Medicine, Peking University Third Hospital, Beijing, PRC"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2006,3,1]]},"reference":[{"key":"BAUM-1993","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1993.tb18338.x"},{"key":"BAUM-AND-WELLNER-1999","doi-asserted-by":"publisher","DOI":"10.1159\/000061125"},{"key":"BOCKMAN-ETAL-2004","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.066399"},{"key":"BYLUND-ETAL-1982","doi-asserted-by":"crossref","unstructured":"Bylund DB, Martinez JR, Pierce DL -1982- Regulation of autonomic receptors in rat submandibular gland. 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