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A literature search was performed for reports of randomized controlled clinical studies, published between 1966 and 2004, the aim of which was the prevention of mucositis in cancer patients undergoing head and neck radiation, chemotherapy, or chemoradiation. The control group consisted of a placebo, no intervention, or another intervention group. Mucositis was scored by either the WHO, the National Cancer Institute-Common Toxicity Criteria (NCI-CTC) score, or the absence or presence of ulcerations, or the presence or absence of grades 3 and 4 mucositis. The meta-analyses included 45 studies fulfilling the inclusion criteria, in which 8 different interventions were evaluated: i.e., local application of chlorhexidine; iseganan; PTA (polymyxin E, tobramycine, and amphotericin B); granulocyte macrophage-colony-stimulating factor\/granulocyte colony-stimulating factor (GM-CSF\/G-CSF); oral cooling; sucralfate and glutamine; and systemic administration of amifostine and GM-CSF\/G-CSF. Four interventions showed a significant preventive effect on the development or severity of oral mucositis: PTA with an odds ratio (OR) = 0.61 (95% confidence interval [CI], 0.39\u20130.96); GM-CSF, OR = 0.53 (CI: 0.33\u20130.87); oral cooling, OR = 0.3 (CI: 0.16\u20130.56); and amifostine, OR = 0.37 (CI: 0.15\u20130.89). To date, no single intervention completely prevents oral mucositis, so combined preventive therapy strategies seem to be required to ensure more successful outcomes.<\/jats:p>","DOI":"10.1177\/154405910608500802","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"690-700","source":"Crossref","is-referenced-by-count":121,"title":["Preventive Intervention Possibilities in Radiotherapy- and                Chemotherapy-induced Oral Mucositis: Results of Meta-analyses"],"prefix":"10.1177","volume":"85","author":[{"given":"M.A.","family":"Stokman","sequence":"first","affiliation":[{"name":"Departments of Oral and Maxillofacial Surgery,"},{"name":"Epidemiology and Statistics, and"},{"name":"Medical Oncology, University of Groningen and University Medical\r               Center Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.K.L.","family":"Spijkervet","sequence":"additional","affiliation":[{"name":"Departments of Oral and Maxillofacial Surgery,"},{"name":"Epidemiology and Statistics, and"},{"name":"Medical Oncology, University of Groningen and University Medical\r               Center Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.M.","family":"Boezen","sequence":"additional","affiliation":[{"name":"Departments of Oral and Maxillofacial Surgery,"},{"name":"Epidemiology and Statistics, and"},{"name":"Medical Oncology, University of Groningen and University Medical\r               Center Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.P.","family":"Schouten","sequence":"additional","affiliation":[{"name":"Departments of Oral and Maxillofacial Surgery,"},{"name":"Epidemiology and Statistics, and"},{"name":"Medical Oncology, University of Groningen and University Medical\r               Center Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.L.N.","family":"Roodenburg","sequence":"additional","affiliation":[{"name":"Departments of Oral and Maxillofacial Surgery,"},{"name":"Epidemiology and Statistics, and"},{"name":"Medical Oncology, University of Groningen and University Medical\r               Center Groningen, P.O. 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