{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T12:32:33Z","timestamp":1777811553614,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p>\n                    A common and significant side-effect of the antidepressant desipramine is xerostomia (dry mouth). We investigated the effect of desipramine on Na\n                    <jats:sup>+<\/jats:sup>\n                    \/H\n                    <jats:sup>+<\/jats:sup>\n                    exchanger, which is an important modulator of salivary secretion. In dissociated human submandibular acinar cells, desipramine inhibited intracellular pH recovery in a concentration-dependent manner. Likewise, 5-(N-ethyl-N-isopropyl)amiloride (EIPA), a Na\n                    <jats:sup>+<\/jats:sup>\n                    \/H\n                    <jats:sup>+<\/jats:sup>\n                    exchanger inhibitor, had the same effect as desipramine, whereas the effect of 4,4\u2032-diisothiocyanostilbene-2,2\u2032-disulphonic acid (DIDS), a Na\n                    <jats:sup>+<\/jats:sup>\n                    \/HCO\n                    <jats:sub>3<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    co-transporter inhibitor, was not dramatic. Although desipramine is known to inhibit catecholamine re-uptake, desipramine also inhibited pH recovery in the human submandibular gland cell line, HSG cells, which lack nerve inputs. Our results suggest that desipramine directly inhibits Na\n                    <jats:sup>+<\/jats:sup>\n                    \/H\n                    <jats:sup>+<\/jats:sup>\n                    exchange in human submandibular glands without the involvement of catecholamine re-uptake, revealing the cellular mechanism of desipramine-evoked xerostomia.\n                  <\/jats:p>","DOI":"10.1177\/154405910608500912","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"839-843","source":"Crossref","is-referenced-by-count":11,"title":["Desipramine Inhibits Na\n                    <sup>+<\/sup>\n                    \/H\n                    <sup>+<\/sup>\n                    Exchanger in Human Submandibular Cells"],"prefix":"10.1177","volume":"85","author":[{"given":"S.-Y.","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Physiology and"},{"name":"Department of Oral and Maxillofacial Surgery, School of Dentistry and Dental Research Institute, Seoul National University, Seoul 110-749, Korea; and"},{"name":"Department of Physiology, Cheju National University College of Medicine, Jeju 690-756, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Physiology and"},{"name":"Department of Oral and Maxillofacial Surgery, School of Dentistry and Dental Research Institute, Seoul National University, Seoul 110-749, Korea; and"},{"name":"Department of Physiology, Cheju National University College of Medicine, Jeju 690-756, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.-H.","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Physiology and"},{"name":"Department of Oral and Maxillofacial Surgery, School of Dentistry and Dental Research Institute, Seoul National University, Seoul 110-749, Korea; and"},{"name":"Department of Physiology, Cheju National University College of Medicine, Jeju 690-756, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Physiology and"},{"name":"Department of Oral and Maxillofacial Surgery, School of Dentistry and Dental Research Institute, Seoul National University, Seoul 110-749, Korea; and"},{"name":"Department of Physiology, Cheju National University College of Medicine, Jeju 690-756, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.B.","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Physiology and"},{"name":"Department of Oral and Maxillofacial Surgery, School of Dentistry and Dental Research Institute, Seoul National University, Seoul 110-749, Korea; and"},{"name":"Department of Physiology, Cheju National University College of Medicine, Jeju 690-756, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.-S.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Physiology and"},{"name":"Department of Oral and Maxillofacial Surgery, School of Dentistry and Dental Research Institute, Seoul National University, Seoul 110-749, Korea; and"},{"name":"Department of Physiology, Cheju National University College of Medicine, Jeju 690-756, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.-H.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Physiology and"},{"name":"Department of Oral and Maxillofacial Surgery, School of Dentistry and Dental Research Institute, Seoul National University, Seoul 110-749, Korea; and"},{"name":"Department of Physiology, Cheju National University College of Medicine, Jeju 690-756, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Physiology and"},{"name":"Department of Oral and Maxillofacial Surgery, School of Dentistry and Dental Research Institute, Seoul National University, Seoul 110-749, Korea; and"},{"name":"Department of Physiology, Cheju National University College of Medicine, Jeju 690-756, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2006,9,1]]},"reference":[{"key":"AMBUDKAR-2000","doi-asserted-by":"publisher","DOI":"10.1177\/10454411000110010301"},{"key":"ARREOLA-ETAL-2002","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.021980"},{"key":"BERGDAHL-AND-BERGDAHL-2000","doi-asserted-by":"publisher","DOI":"10.1177\/00220345000790090301"},{"key":"CAMPOS-BARROS-AND-BAUMGARTNER-1994","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(94)91156-8"},{"key":"EVANS-ETAL-2000","doi-asserted-by":"crossref","unstructured":"Evans RL, Park K, Turner RJ, Watson GE, Nguyen HV, Dennett MR,\n                      et al.\n                      (2000). 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