{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T12:28:48Z","timestamp":1777811328357,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p>\n                    A molecular basis for Cl\n                    <jats:sup>\u2212<\/jats:sup>\n                    re-absorption has not been well-characterized in salivary ductal cells. Previously, we found strong expression of a rat homologue proposed to be Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -dependent Cl\n                    <jats:sup>\u2212<\/jats:sup>\n                    channels (rCLCA) in the intralobular ducts of the rat submandibular gland. To address the question as to whether rCLCA and cystic fibrosis transmembrane conductance regulator (CFTR) are involved in Cl\n                    <jats:sup>\u2212<\/jats:sup>\n                    re-absorption, we evaluated the electrolyte content of saliva from glands pre-treated with a small interfering RNA (siRNA). Retrograde injection into a given submandibular duct of an siRNA designed to knock down either rCLCA or CFTR reduced the expression of each of the proteins. rCLCA and CFTR siRNAs significantly increased Cl\n                    <jats:sup>\u2212<\/jats:sup>\n                    concentration in the final saliva during pilocarpine stimulation. These results represent the first in vivo evidence for a physiological significance of rCLCA, along with CFTR, in transepithelial Cl\n                    <jats:sup>\u2212<\/jats:sup>\n                    transport in the ductal system of the rat submandibular gland.\n                  <\/jats:p>","DOI":"10.1177\/154405910608501207","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"1101-1105","source":"Crossref","is-referenced-by-count":22,"title":["Roles of CLCA and CFTR in Electrolyte Re-absorption from Rat Saliva"],"prefix":"10.1177","volume":"85","author":[{"given":"K.","family":"Ishibashi","sequence":"first","affiliation":[{"name":"Departments of Functional Bioscience,"},{"name":"Physiological Science & Molecular Biology, and"},{"name":"Morphological Biology, Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, Fukuoka 814-0193, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Departments of Functional Bioscience,"},{"name":"Physiological Science & Molecular Biology, and"},{"name":"Morphological Biology, Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, Fukuoka 814-0193, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Okamura","sequence":"additional","affiliation":[{"name":"Departments of Functional Bioscience,"},{"name":"Physiological Science & Molecular Biology, and"},{"name":"Morphological Biology, Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, Fukuoka 814-0193, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Teng","sequence":"additional","affiliation":[{"name":"Departments of Functional Bioscience,"},{"name":"Physiological Science & Molecular Biology, and"},{"name":"Morphological Biology, Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, Fukuoka 814-0193, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Departments of Functional Bioscience,"},{"name":"Physiological Science & Molecular Biology, and"},{"name":"Morphological Biology, Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, Fukuoka 814-0193, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Abe","sequence":"additional","affiliation":[{"name":"Departments of Functional Bioscience,"},{"name":"Physiological Science & Molecular Biology, and"},{"name":"Morphological Biology, Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, Fukuoka 814-0193, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2006,12,1]]},"reference":[{"key":"ALTSCHUL-ETAL-1997","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.17.3389"},{"key":"APS-ETAL-2002","doi-asserted-by":"crossref","unstructured":"Aps JK, Delanghe J, Martens LC -2002- Salivary electrolyte concentrations are associated with cystic fibrosis transmembrane regulator genotypes. 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