{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:29:16Z","timestamp":1790972956797,"version":"4.1.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:p>Periodontitis is characterized by periodontal tissue destruction. Since interleukin-17 (IL-17) has been reported to up-regulate IL-1\u03b2 and tumor necrosis factor-alpha (TNF-\u03b1), it was hypothesized that it is increased in periodontitis and up-regulates these cytokines and tissue-destructive matrix metalloproteinases (MMP) in local migrant and resident cells. Immunocytochemistry disclosed elevated IL-1\u03b2, TNF-\u03b1, and IL-17 levels in periodontitis. These cytokines induced proMMP-1 and especially MMP-3 in gingival fibroblasts, whereas MMP-8 and MMP-9 were not induced. IL-17 was less potent as a direct MMP inducer than IL-1\u03b2 and TNF-\u03b1, but it induced IL-1\u03b2 and TNF-\u03b1 production from macrophages, and IL-6 and IL-8 from gingival fibroblasts. In accordance with these findings, immunocytochemistry disclosed that MMP-1 and MMP-3 were increased in periodontitis. Gingival fibroblasts may play an important role in tissue destruction in periodontitis via cytokine-inducible MMP-1 and MMP-3 production, in which IL-17 plays a role as a key regulatory cytokine.<\/jats:p>","DOI":"10.1177\/154405910708600409","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"347-351","source":"Crossref","is-referenced-by-count":209,"title":["MMPs, IL-1, and TNF are Regulated by IL-17 in Periodontitis"],"prefix":"10.1177","volume":"86","author":[{"given":"A.","family":"Beklen","sequence":"first","affiliation":[{"name":"Department of Medicine\/Inv\u00e4rtes medicin, Helsinki University Central Hospital, Helsinki, Finland;"},{"name":"Institute of Biomedicine\/Anatomy, University of Helsinki, Finland;"},{"name":"Medico-social Centre, Dental Clinic, Bogazici University, Istanbul, Turkey;"},{"name":"ORTON Orthopaedic Hospital of the Invalid Foundation, Helsinki, Finland;"},{"name":"Department of Periodontology, Faculty of Dentistry, Ankara University, Turkey;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ainola","sequence":"additional","affiliation":[{"name":"Department of Medicine\/Inv\u00e4rtes medicin, Helsinki University Central Hospital, Helsinki, Finland;"},{"name":"Institute of Biomedicine\/Anatomy, University of Helsinki, Finland;"},{"name":"Medico-social Centre, Dental Clinic, Bogazici University, Istanbul, Turkey;"},{"name":"ORTON Orthopaedic Hospital of the Invalid Foundation, Helsinki, Finland;"},{"name":"Department of Periodontology, Faculty of Dentistry, Ankara University, Turkey;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Hukkanen","sequence":"additional","affiliation":[{"name":"Department of Medicine\/Inv\u00e4rtes medicin, Helsinki University Central Hospital, Helsinki, Finland;"},{"name":"Institute of Biomedicine\/Anatomy, University of Helsinki, Finland;"},{"name":"Medico-social Centre, Dental Clinic, Bogazici University, Istanbul, Turkey;"},{"name":"ORTON Orthopaedic Hospital of the Invalid Foundation, Helsinki, Finland;"},{"name":"Department of Periodontology, Faculty of Dentistry, Ankara University, Turkey;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"G\u00fcrgan","sequence":"additional","affiliation":[{"name":"Department of Medicine\/Inv\u00e4rtes medicin, Helsinki University Central Hospital, Helsinki, Finland;"},{"name":"Institute of Biomedicine\/Anatomy, University of Helsinki, Finland;"},{"name":"Medico-social Centre, Dental Clinic, Bogazici University, Istanbul, Turkey;"},{"name":"ORTON Orthopaedic Hospital of the Invalid Foundation, Helsinki, Finland;"},{"name":"Department of Periodontology, Faculty of Dentistry, Ankara University, Turkey;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Sorsa","sequence":"additional","affiliation":[{"name":"Department of Medicine\/Inv\u00e4rtes medicin, Helsinki University Central Hospital, Helsinki, Finland;"},{"name":"Institute of Biomedicine\/Anatomy, University of Helsinki, Finland;"},{"name":"Medico-social Centre, Dental Clinic, Bogazici University, Istanbul, Turkey;"},{"name":"ORTON Orthopaedic Hospital of the Invalid Foundation, Helsinki, Finland;"},{"name":"Department of Periodontology, Faculty of Dentistry, Ankara University, Turkey;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.T.","family":"Konttinen","sequence":"additional","affiliation":[{"name":"Department of Medicine\/Inv\u00e4rtes medicin, Helsinki University Central Hospital, Helsinki, Finland;"},{"name":"Institute of Biomedicine\/Anatomy, University of Helsinki, Finland;"},{"name":"Medico-social Centre, Dental Clinic, Bogazici University, Istanbul, Turkey;"},{"name":"ORTON Orthopaedic Hospital of the Invalid Foundation, Helsinki, Finland;"},{"name":"Department of Periodontology, Faculty of Dentistry, Ankara University, Turkey;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2007,4,1]]},"reference":[{"key":"ABE-ETAL-2001","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2001.360303.x"},{"key":"AINAMO-AND-BAY-1975","unstructured":"Ainamo J, Bay I (1975). 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