{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:16:18Z","timestamp":1791155778752,"version":"4.1.0"},"reference-count":34,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p>Little is known about the genetic background of keratocystic odontogenic tumors (KCOT, odontogenic keratocysts). Our aim was to characterize genomic aberrations in sporadic KCOT using cDNA-expression arrays and array-comparative genomic hybridization. For cDNA-expression arrays, 10 KCOT specimens and 20 fetal tooth germs were studied. Quantitative real-time reverse-transcription\/polymerase chain-reaction and immunohistochemical studies were also undertaken. Several genes were over-expressed in 12q13, including cytokeratin 6B ( KRT6B) (\u2248 10-fold), epidermal growth factor receptor ERBB3 (~ 4.7-fold), and glioma-associated oncogene homologue 1 ( GLI1) (~ 5- to 12-fold). One amplicon (~ 0.7 Mega base pairs [Mbp]), covering several genes involved in the regulation of cell growth, was found in 12q13.2. Deletions were found in 3q13.1, 5p14.3, and 7q31.3, including the cell-adhesion-related gene cadherin 18 ( CDH18) and leukocyte cell adhesion molecule ( ALCAM, MEMD). Over-expressed and amplified genes in 12q13, also reported in several other tumors and cell lines, may contribute to the persistent growth characteristics of KCOT.<\/jats:p>","DOI":"10.1177\/154405910708600611","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"544-549","source":"Crossref","is-referenced-by-count":22,"title":["Genetic Changes in Sporadic Keratocystic Odontogenic Tumors (Odontogenic Keratocysts)"],"prefix":"10.1177","volume":"86","author":[{"given":"K.","family":"Heikinheimo","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Institute of Dentistry, University of Turku, Lemmink\u00e4isenkatu 2, FIN-20520 Turku, Finland;"},{"name":"Department of Oral Diseases, Turku University Hospital, Lemmink\u00e4isenkatu 2, FIN-20500 Turku, Finland;"},{"name":"Haartman Institute, Department of Pathology, FIN-00014 University of Helsinki, Finland;"},{"name":"Department of Oral Pathology, GKT Dental Institute, King\u2019s College London, United Kingdom; and"},{"name":"Genetic Laboratory, 1st Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.J.","family":"Jee","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Institute of Dentistry, University of Turku, Lemmink\u00e4isenkatu 2, FIN-20520 Turku, Finland;"},{"name":"Department of Oral Diseases, Turku University Hospital, Lemmink\u00e4isenkatu 2, FIN-20500 Turku, Finland;"},{"name":"Haartman Institute, Department of Pathology, FIN-00014 University of Helsinki, Finland;"},{"name":"Department of Oral Pathology, GKT Dental Institute, King\u2019s College London, United Kingdom; and"},{"name":"Genetic Laboratory, 1st Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.R.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Institute of Dentistry, University of Turku, Lemmink\u00e4isenkatu 2, FIN-20520 Turku, Finland;"},{"name":"Department of Oral Diseases, Turku University Hospital, Lemmink\u00e4isenkatu 2, FIN-20500 Turku, Finland;"},{"name":"Haartman Institute, Department of Pathology, FIN-00014 University of Helsinki, Finland;"},{"name":"Department of Oral Pathology, GKT Dental Institute, King\u2019s College London, United Kingdom; and"},{"name":"Genetic Laboratory, 1st Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Nagy","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Institute of Dentistry, University of Turku, Lemmink\u00e4isenkatu 2, FIN-20520 Turku, Finland;"},{"name":"Department of Oral Diseases, Turku University Hospital, Lemmink\u00e4isenkatu 2, FIN-20500 Turku, Finland;"},{"name":"Haartman Institute, Department of Pathology, FIN-00014 University of Helsinki, Finland;"},{"name":"Department of Oral Pathology, GKT Dental Institute, King\u2019s College London, United Kingdom; and"},{"name":"Genetic Laboratory, 1st Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Knuutila","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Institute of Dentistry, University of Turku, Lemmink\u00e4isenkatu 2, FIN-20520 Turku, Finland;"},{"name":"Department of Oral Diseases, Turku University Hospital, Lemmink\u00e4isenkatu 2, FIN-20500 Turku, Finland;"},{"name":"Haartman Institute, Department of Pathology, FIN-00014 University of Helsinki, Finland;"},{"name":"Department of Oral Pathology, GKT Dental Institute, King\u2019s College London, United Kingdom; 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