{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T12:35:17Z","timestamp":1777811717212,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p>\n                    Endothelial vasodilatory substances may play a central role in the local regulation of vascular tone. We hypothesized that these substances can mediate endothelium-dependent vasodilatory responses to acetylcholine (ACh) and vasoactive intestinal peptide (VIP) in the human submandibular artery. We evaluated the contributions of endothelial vasodilatory substances to vessel relaxation in response to ACh and VIP, using different inhibitors of endothelial vasodilation, the nitric oxide synthase inhibitor, the cyclo-oxygenase inhibitor, indomethacin, the potassium channel blocker, and 4-aminopyridine. ACh and VIP caused an endothelium- and concentration-dependent relaxation in this artery. ACh relaxation was completely blocked after the concomitant addition of N\n                    <jats:sup>G<\/jats:sup>\n                    -nitro-L-arginine and indomethacin. The vasorelaxant effect of ACh was not influenced by 4-aminopyridine. VIP relaxation was almost completely abolished by 4-aminopyridine, and was partly inhibited by N\n                    <jats:sup>G<\/jats:sup>\n                    -nitro-L-arginine, but was not affected by indomethacin. Thus, in the human submandibular artery, ACh and VIP produced endothelium-dependent vasodilation with different underlying mechanisms: release of nitric oxide (NO) and cyclo-oxygenase products for ACh, and release of NO and endothelium-derived hyperpolarizing factor for VIP.\n                  <\/jats:p>","DOI":"10.1177\/154405910708600615","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"565-570","source":"Crossref","is-referenced-by-count":5,"title":["Responses of the Human Submandibular Artery to ACh and VIP"],"prefix":"10.1177","volume":"86","author":[{"given":"D.","family":"Stoji\u0107","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Stomatology, University of Belgrade, Dr. Suboti\u0107a br. 8, 11 000 Belgrade;"},{"name":"Department of Pharmacology, Medical Faculty, University of Ni\u0161;"},{"name":"Department of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade; and"},{"name":"Department of Maxillofacial Surgery, Medical Faculty, University of Ni\u0161, Serbia and Montenegro"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Pe\u0161i\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Stomatology, University of Belgrade, Dr. Suboti\u0107a br. 8, 11 000 Belgrade;"},{"name":"Department of Pharmacology, Medical Faculty, University of Ni\u0161;"},{"name":"Department of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade; and"},{"name":"Department of Maxillofacial Surgery, Medical Faculty, University of Ni\u0161, Serbia and Montenegro"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Radenkovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Stomatology, University of Belgrade, Dr. Suboti\u0107a br. 8, 11 000 Belgrade;"},{"name":"Department of Pharmacology, Medical Faculty, University of Ni\u0161;"},{"name":"Department of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade; and"},{"name":"Department of Maxillofacial Surgery, Medical Faculty, University of Ni\u0161, Serbia and Montenegro"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Popovi\u0107-Roganovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Stomatology, University of Belgrade, Dr. Suboti\u0107a br. 8, 11 000 Belgrade;"},{"name":"Department of Pharmacology, Medical Faculty, University of Ni\u0161;"},{"name":"Department of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade; and"},{"name":"Department of Maxillofacial Surgery, Medical Faculty, University of Ni\u0161, Serbia and Montenegro"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Pe\u0161i\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Stomatology, University of Belgrade, Dr. Suboti\u0107a br. 8, 11 000 Belgrade;"},{"name":"Department of Pharmacology, Medical Faculty, University of Ni\u0161;"},{"name":"Department of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade; and"},{"name":"Department of Maxillofacial Surgery, Medical Faculty, University of Ni\u0161, Serbia and Montenegro"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Grbovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Stomatology, University of Belgrade, Dr. Suboti\u0107a br. 8, 11 000 Belgrade;"},{"name":"Department of Pharmacology, Medical Faculty, University of Ni\u0161;"},{"name":"Department of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade; and"},{"name":"Department of Maxillofacial Surgery, Medical Faculty, University of Ni\u0161, Serbia and Montenegro"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,6,1]]},"reference":[{"key":"ANDERSON-AND-GARRETT-2004","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2003.09.004"},{"key":"BARTSCH-ETAL-1996","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(96)12910-4"},{"key":"BRIZZOLARA-AND-BURNSTOCK-1991","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1991.tb12325.x"},{"key":"CHAN-AND-FISCUS-2003","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-200303000-00012"},{"key":"CORRIU-ETAL-1996","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15765.x"},{"key":"DORLEANS-JUSTE-ETAL-1985","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(85)90515-1"},{"key":"DAVIES-AND-WILLIAMS-1984","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(84)90073-X"},{"key":"DAWIDSON-ETAL-1997","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(96)00627-3"},{"key":"EDWARDS-1998","doi-asserted-by":"crossref","unstructured":"Edwards AV (1998). Autonomic control of salivary blood flow. In: Glandular mechanisms of salivary secretion. Garrett JR, Ekstr\u00f6m J, Anderson LC, editors. Frontiers of Oral Biology. Vol. 10. Basel: Karger, pp. 101\u2013117.","DOI":"10.1159\/000061091"},{"key":"EKSTROM-1999","doi-asserted-by":"crossref","unstructured":"Ekstr\u00f6m J (1999). Role of nonadrenergic, noncholinergic autonomic transmitters in salivary glandular activities\n                      in vivo\n                      . In: Neural mechanisms of salivary gland secretion. Garrett JR, Ekstr\u00f6m J, Anderson LC, editors. Frontiers of Oral Biology. Vol. 11. Basel: Karger, pp. 94\u2013130.","DOI":"10.1159\/000061124"},{"key":"FISCUS-1988","unstructured":"Fiscus RR (1988). Molecular mechanisms of endothelium-mediated vasodilation. Semin Thromb Hemost 14:12\u201322."},{"key":"GAGE-AND-PICKETT-2003","unstructured":"Gage TW, Pickett FA (2003). Mosby\u2019s dental drug reference. 6th ed. St. Louis: Mosby."},{"key":"GARRETT-1967","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(67)90179-3"},{"key":"IGNARRO-ETAL-1987A","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.24.9265"},{"key":"IGNARRO-ETAL-1987B","doi-asserted-by":"crossref","unstructured":"Ignarro LJ, Byrns RE, Buga GM, Wood KS (1987b). Mechanisms of endothelium-dependent vascular smooth muscle relaxation elicited by bradykinin and VIP. Am J Physiol 253(5 Pt 2):H1074\u2013H1082.","DOI":"10.1152\/ajpheart.1987.253.5.H1074"},{"key":"KOJDA-AND-HARRISON-1999","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(99)00169-8"},{"key":"KUSAKABE-ETAL-1997","doi-asserted-by":"publisher","DOI":"10.1007\/s004410050789"},{"key":"LARSSON-ETAL-1986","doi-asserted-by":"publisher","DOI":"10.1016\/0167-0115(86)90049-2"},{"key":"LEE-ETAL-1984","doi-asserted-by":"publisher","DOI":"10.1126\/science.6719122"},{"key":"LUNDBERG-ETAL-1981","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1981.tb06902.x"},{"key":"MOMBOULI-ETAL-1996","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.0621"},{"key":"PALMER-ETAL-1987","doi-asserted-by":"publisher","DOI":"10.1038\/327524a0"},{"key":"SATA-ETAL-1988","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(88)90133-7"},{"key":"STOJIC-ETAL-2003","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0722.2003.00021.x"},{"key":"SUAREZ-CUNQUEIRO-ETAL-2002","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2002.127165"},{"key":"VANHOUTTE-1997","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/18.suppl_E.19"}],"container-title":["Journal of Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/154405910708600615","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/154405910708600615","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/154405910708600615","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:03:56Z","timestamp":1777496636000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/154405910708600615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["10.1177\/154405910708600615"],"URL":"https:\/\/doi.org\/10.1177\/154405910708600615","relation":{},"ISSN":["0022-0345","1544-0591"],"issn-type":[{"value":"0022-0345","type":"print"},{"value":"1544-0591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}