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We used scanning electron microscopy and quantitative electron-probe microanalysis to compare dentin and enamel from healthy and fluorotic teeth. The dentin in fluorotic teeth was characterized by a highly mineralized sclerotic pattern, in comparison with control teeth (p &lt; 0.001) and fluorotic enamel lesions (p &lt; 0.001). Enamel near the lesions showed hypercalcification in comparison with dentin (p &lt; 0.001). In response to the effects of severe fluorosis in the enamel, the dentin showed hypermineralization, as found in other enamel disorders. The hypermineralization response of the dentin in our samples suggests that the mechanism of the response should be taken into account in dental caries and other dental disorders associated with severe fluorosis.<\/jats:p>","DOI":"10.1177\/154405910708600910","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"857-861","source":"Crossref","is-referenced-by-count":14,"title":["Dentin in Severe Fluorosis: a Quantitative Histochemical Study"],"prefix":"10.1177","volume":"86","author":[{"given":"F.","family":"Rojas-S\u00e1nchez","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones Odontol\u00f3gicas Ra\u00fal Vincentelli, Facultad de Odontolog\u00eda, Universidad Central de Venezuela, Caracas, Venezuela; and"},{"name":"Departamento de Histolog\u00eda, Facultad de Medicina y Odontolog\u00eda, Universidad de Granada, E-18071 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Alaminos","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Odontol\u00f3gicas Ra\u00fal Vincentelli, Facultad de Odontolog\u00eda, Universidad Central de Venezuela, Caracas, Venezuela; and"},{"name":"Departamento de Histolog\u00eda, Facultad de Medicina y Odontolog\u00eda, Universidad de Granada, E-18071 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Campos","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Odontol\u00f3gicas Ra\u00fal Vincentelli, Facultad de Odontolog\u00eda, Universidad Central de Venezuela, Caracas, Venezuela; and"},{"name":"Departamento de Histolog\u00eda, Facultad de Medicina y Odontolog\u00eda, Universidad de Granada, E-18071 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Rivera","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Odontol\u00f3gicas Ra\u00fal Vincentelli, Facultad de Odontolog\u00eda, Universidad Central de Venezuela, Caracas, Venezuela; and"},{"name":"Departamento de Histolog\u00eda, Facultad de Medicina y Odontolog\u00eda, Universidad de Granada, E-18071 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.C.","family":"S\u00e1nchez-Quevedo","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Odontol\u00f3gicas Ra\u00fal Vincentelli, Facultad de Odontolog\u00eda, Universidad Central de Venezuela, Caracas, Venezuela; and"},{"name":"Departamento de Histolog\u00eda, Facultad de Medicina y Odontolog\u00eda, Universidad de Granada, E-18071 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,9,1]]},"reference":[{"key":"AOBA-AND-FEJERSKOV-2002","doi-asserted-by":"publisher","DOI":"10.1177\/154411130201300206"},{"key":"APPLETON-ETAL-2000","doi-asserted-by":"publisher","DOI":"10.1159\/000016789"},{"key":"BRAVO-ETAL-1996","doi-asserted-by":"publisher","DOI":"10.1177\/00220345960750020601"},{"key":"CAMPOS-ETAL-2000","unstructured":"Campos A, Rodriguez IA, S\u00e1nchez-Quevedo MC, Garc\u00eda JM, Nieto-Albano OH, G\u00f3mez de Ferraris ME (2000). 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