{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T12:34:53Z","timestamp":1777811693614,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:p>Inorganic polyphosphates [Poly(P)] are often distributed in osteoblasts. We undertook the present study to verify the hypothesis that Poly(P) stimulates osteoblasts and facilitates bone formation. The osteoblast-like cell line MC 3T3-E1 was cultured with Poly(P), and gene expression and potential mineralization were evaluated by reverse-transcription polymerase chain-reaction. Alkaline phosphatase activity, von Kossa staining, and resorption pit formation analyses were also determined. The potential role of Poly(P) in bone formation was assessed in a rat alveolar bone regeneration model. Poly(P) induced osteopontin, osteocalcin, collagen 1\u03b1, and osteoprotegerin expression and increased alkaline phosphatase activity in MC 3T3-E1 cells. Dentin slice pit formation decreased with mouse osteoblast and bone marrow macrophage co-cultivation in the presence of Poly(P). Promotion of alveolar bone regeneration was observed locally in Poly(P)-treated rats. These findings suggest that Poly(P) plays a role in osteoblastic differentiation, activation, and bone mineralization. Thus, local poly(P) delivery may have a therapeutic benefit in periodontal disease.<\/jats:p>","DOI":"10.1177\/154405910708600917","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"893-897","source":"Crossref","is-referenced-by-count":67,"title":["Inorganic Polyphosphate: a Possible Stimulant of Bone Formation"],"prefix":"10.1177","volume":"86","author":[{"given":"Y.","family":"Hacchou","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery,"},{"name":"Institute for Oral Science,"},{"name":"Department of Oral Microbiology, and"},{"name":"Department of Orthodontics, Matsumoto Dental University School of Dentistry, 1780 Gobara Hirooka, Shiojiri, Nagano 399-0874, Japan; and"},{"name":"Regenetiss Inc., 1-5-17, Akabane, Okaya, Nagano 394-0002, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Uematsu","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery,"},{"name":"Institute for Oral Science,"},{"name":"Department of Oral Microbiology, and"},{"name":"Department of Orthodontics, Matsumoto Dental University School of Dentistry, 1780 Gobara Hirooka, Shiojiri, Nagano 399-0874, Japan; 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