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Thus, depriving a tumor of its vascular supply by means of anti-angiogenic agents has been of great interest since its proposal in the 1970s. This review looks at the common angiogenic inhibitors (angiostatin, endostatin, maspin, pigment epithelium-derived factor, bevacizumab and other monoclonal antibodies, and zoledronic acid) and their current status in clinical trials.<\/jats:p>","DOI":"10.1177\/154405910708601005","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"927-936","source":"Crossref","is-referenced-by-count":24,"title":["Angiogenesis Inhibitors and the Need for Anti-angiogenic Therapeutics"],"prefix":"10.1177","volume":"86","author":[{"given":"C.R.","family":"Dass","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, University of Melbourne, St. Vincent\u2019s Health, P.O. Box 2900, Fitzroy, 3065, Melbourne, Australia; and"},{"name":"Bone and Soft Tissue Sarcoma Service, Peter MacCallum Cancer Centre, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.M.N.","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, University of Melbourne, St. Vincent\u2019s Health, P.O. Box 2900, Fitzroy, 3065, Melbourne, Australia; and"},{"name":"Bone and Soft Tissue Sarcoma Service, Peter MacCallum Cancer Centre, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.F.M.","family":"Choong","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, University of Melbourne, St. Vincent\u2019s Health, P.O. Box 2900, Fitzroy, 3065, Melbourne, Australia; and"},{"name":"Bone and Soft Tissue Sarcoma Service, Peter MacCallum Cancer Centre, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,10,1]]},"reference":[{"key":"ABE-ETAL-2004","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63210-5"},{"key":"ADAIR-ETAL-1990","doi-asserted-by":"crossref","unstructured":"Adair TH, Gay WJ, Montani JP -1990- Growth regulation of the vascular system: evidence for a metabolic hypothesis. 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