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Despite these benefits, osteonecrosis of the jaws has recently emerged as a significant complication in a subset of patients receiving these drugs. Based on a growing number of case reports and institutional reviews, bisphosphonate therapy may cause exposed and necrotic bone that is isolated to the jaw. This complication usually presents following simple dento-alveolar surgery, and can cause a significant adverse effect on the quality of life for most patients. The pathogenesis for this complication appears to be related to the profound inhibition of osteoclast function and bone remodeling.<\/jats:p>","DOI":"10.1177\/154405910708601101","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"1013-1021","source":"Crossref","is-referenced-by-count":111,"title":["Osteonecrosis of the Jaws and Bisphosphonate Therapy"],"prefix":"10.1177","volume":"86","author":[{"given":"S.L.","family":"Ruggiero","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Stony Brook School of Dental Medicine, Long Island Jewish Medical Center, Division of Oral and Maxillofacial Surgery, New Hyde Park, NY; and"},{"name":"New York Center for Orthognathic and Maxillofacial Surgery, 2001 Marcus Ave., Suite N10, Lake Success, NY 11042, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.J.","family":"Drew","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Stony Brook School of Dental Medicine, Long Island Jewish Medical Center, Division of Oral and Maxillofacial Surgery, New Hyde Park, NY; and"},{"name":"New York Center for Orthognathic and Maxillofacial Surgery, 2001 Marcus Ave., Suite N10, Lake Success, NY 11042, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,11,1]]},"reference":[{"key":"ABRAMS-ETAL-1950","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1950)3:1<74::AID-CNCR2820030111>3.0.CO;2-7"},{"key":"ADA-2006","unstructured":"ADA -2006- Report of the Council of Scientific Affairs. 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