{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T12:33:52Z","timestamp":1777811632388,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:p>The primary and modifier genes that regulate normal maxillofacial development are unknown. Previous quantitative trait locus (QTL) analyses using the F2 progeny of 2 mouse strains, DBA\/2J (short snout\/wide face) and C57BL\/6J (long snout\/narrow face), revealed a significant logarithm-of-odds (LOD) score for snout length on mouse chromosome 12 at 44 centimorgan (cM). We further sought to validate this locus contributing to anterior-posterior dimensions of the upper mid-face at the D12Mit7 marker in a 44-centimorgan portion of chromosome 12. Congenic mice carrying introgressed DNA from DBA\/2J on a C57BL\/6J background were selected for submental vertex cephalometric imaging. Results confirmed QTLs, determining that short snout length (P &lt; 0.05) and face width relative to snout length (P &lt; 0.01) were present in the 44-cM region of chromosome 12. We conclude that one or more genes contributing to the shape of the maxillary complex are located near 44 cM of mouse chromosome 12.<\/jats:p>","DOI":"10.1177\/154405910708601212","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"1203-1206","source":"Crossref","is-referenced-by-count":7,"title":["A Genome Segment on Mouse Chromosome 12 Determines Maxillary Growth"],"prefix":"10.1177","volume":"86","author":[{"given":"J.","family":"Oh","sequence":"first","affiliation":[{"name":"Section of Orthodontics, UCLA School of Dentistry, 43-091 Center for the Health Sciences, Box 951668, Los Angeles, CA 90095-1668, USA;"},{"name":"The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, Biomaterials and Hospital Dentistry, UCLA School of Dentistry; and"},{"name":"Cardiology Division, Department of Medicine, The David Geffen School of Medicine at UCLA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.J.","family":"Wang","sequence":"additional","affiliation":[{"name":"Section of Orthodontics, UCLA School of Dentistry, 43-091 Center for the Health Sciences, Box 951668, Los Angeles, CA 90095-1668, USA;"},{"name":"The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, Biomaterials and Hospital Dentistry, UCLA School of Dentistry; and"},{"name":"Cardiology Division, Department of Medicine, The David Geffen School of Medicine at UCLA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Poole","sequence":"additional","affiliation":[{"name":"Section of Orthodontics, UCLA School of Dentistry, 43-091 Center for the Health Sciences, Box 951668, Los Angeles, CA 90095-1668, USA;"},{"name":"The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, Biomaterials and Hospital Dentistry, UCLA School of Dentistry; and"},{"name":"Cardiology Division, Department of Medicine, The David Geffen School of Medicine at UCLA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Kim","sequence":"additional","affiliation":[{"name":"Section of Orthodontics, UCLA School of Dentistry, 43-091 Center for the Health Sciences, Box 951668, Los Angeles, CA 90095-1668, USA;"},{"name":"The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, Biomaterials and Hospital Dentistry, UCLA School of Dentistry; and"},{"name":"Cardiology Division, Department of Medicine, The David Geffen School of Medicine at UCLA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.C.","family":"Davis","sequence":"additional","affiliation":[{"name":"Section of Orthodontics, UCLA School of Dentistry, 43-091 Center for the Health Sciences, Box 951668, Los Angeles, CA 90095-1668, USA;"},{"name":"The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, Biomaterials and Hospital Dentistry, UCLA School of Dentistry; and"},{"name":"Cardiology Division, Department of Medicine, The David Geffen School of Medicine at UCLA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Section of Orthodontics, UCLA School of Dentistry, 43-091 Center for the Health Sciences, Box 951668, Los Angeles, CA 90095-1668, USA;"},{"name":"The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, Biomaterials and Hospital Dentistry, UCLA School of Dentistry; and"},{"name":"Cardiology Division, Department of Medicine, The David Geffen School of Medicine at UCLA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.-K.","family":"Pae","sequence":"additional","affiliation":[{"name":"Section of Orthodontics, UCLA School of Dentistry, 43-091 Center for the Health Sciences, Box 951668, Los Angeles, CA 90095-1668, USA;"},{"name":"The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, Biomaterials and Hospital Dentistry, UCLA School of Dentistry; and"},{"name":"Cardiology Division, Department of Medicine, The David Geffen School of Medicine at UCLA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,12,1]]},"reference":[{"key":"BELKNAP-ETAL-1996","doi-asserted-by":"publisher","DOI":"10.1007\/BF02359892"},{"key":"BIRKELAND-ETAL-2000","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/22.5.509"},{"key":"CHESLER-ETAL-2005","doi-asserted-by":"publisher","DOI":"10.1038\/ng1518"},{"key":"CHEVERUD-ETAL-2004","doi-asserted-by":"crossref","unstructured":"Cheverud JM, Ehrich TH, Vaughn TT, Koreishi SF, Linsey RB, Pletscher LS -2004- Pleiotropic effects on mandibular morphology II: differential epistasis and genetic variation in morphological integration. 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