{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:50:18Z","timestamp":1790833818487,"version":"4.1.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:p>\n                    The interaction between epithelial and mesenchymal tissues plays a critical role in the development of organs such as teeth, lungs, and hair. During tooth development, fibroblast growth factor (FGF) signaling is critical for regulating reciprocal epithelial and mesenchymal interactions. FGF signaling requires FGF ligands and their receptors (FGFRs). In this study, we investigated the role of epithelial FGF signaling in tooth development, using the\n                    <jats:italic toggle=\"yes\">Cre-loxp<\/jats:italic>\n                    system to create tissue-specific inactivation of\n                    <jats:italic toggle=\"yes\">Fgfr1<\/jats:italic>\n                    in mice. In\n                    <jats:italic toggle=\"yes\">K14-Cre;Fgfr1<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic toggle=\"yes\">fl\/fl<\/jats:italic>\n                    <\/jats:sup>\n                    mice, the apical sides of enamel-secreting ameloblasts failed to adhere properly to each other, although ameloblast differentiation was unaffected at early stages. Prior to eruption, enamel structure was compromised in the\n                    <jats:italic toggle=\"yes\">K14-Cre;Fgfr1<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic toggle=\"yes\">fl\/fl<\/jats:italic>\n                    <\/jats:sup>\n                    mice and displayed severe enamel defects that mimic amelogenesis imperfecta (AI), with a rough, irregular enamel surface. These results suggest that there is a cell-autonomous requirement for FGF signaling in the dental epithelium during enamel formation. Loss of\n                    <jats:italic toggle=\"yes\">Fgfr1<\/jats:italic>\n                    affects ameloblast organization at the enamel-secretory stage and, hence, the formation of enamel.\n                  <\/jats:p>","DOI":"10.1177\/154405910808700307","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"238-243","source":"Crossref","is-referenced-by-count":32,"title":["Epithelial Fibroblast Growth Factor Receptor 1 Regulates Enamel Formation"],"prefix":"10.1177","volume":"87","author":[{"given":"K.","family":"Takamori","sequence":"first","affiliation":[{"name":"Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA; and"},{"name":"Division of Pediatric Dentistry, Department of Human Development &amp; Fostering, Meikai University School of Dentistry, 1-1 Keyaki-dai, Sakado, Saitama, 350-0283, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Hosokawa","sequence":"additional","affiliation":[{"name":"Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA; and"},{"name":"Division of Pediatric Dentistry, Department of Human Development &amp; Fostering, Meikai University School of Dentistry, 1-1 Keyaki-dai, Sakado, Saitama, 350-0283, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Xu","sequence":"additional","affiliation":[{"name":"Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA; and"},{"name":"Division of Pediatric Dentistry, Department of Human Development &amp; Fostering, Meikai University School of Dentistry, 1-1 Keyaki-dai, Sakado, Saitama, 350-0283, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Deng","sequence":"additional","affiliation":[{"name":"Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA; and"},{"name":"Division of Pediatric Dentistry, Department of Human Development &amp; Fostering, Meikai University School of Dentistry, 1-1 Keyaki-dai, Sakado, Saitama, 350-0283, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"P.","family":"Bringas","sequence":"additional","affiliation":[{"name":"Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA; and"},{"name":"Division of Pediatric Dentistry, Department of Human Development &amp; Fostering, Meikai University School of Dentistry, 1-1 Keyaki-dai, Sakado, Saitama, 350-0283, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Chai","sequence":"additional","affiliation":[{"name":"Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA; and"},{"name":"Division of Pediatric Dentistry, Department of Human Development &amp; Fostering, Meikai University School of Dentistry, 1-1 Keyaki-dai, Sakado, Saitama, 350-0283, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2008,3]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01125"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.120.9.2369"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.6.1642"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(99)00112-4"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.8.1671"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.22.4775"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.3.483"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1122"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00100"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.147.1.105"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.6.1533"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(02)00005-5"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2003.017657"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.40.12.900"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6408(1998)22:4<374::AID-DVG7>3.0.CO;2-3"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0177(2000)9999:9999<::AID-DVDY1062>3.0.CO;2-J"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910508400314"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2004.024505"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/03008200390152205"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_1997_034_0417_cmipwk_2.3.co_2"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2005.01176.x"},{"key":"e_1_3_3_23_1","first-page":"REVIEWS3005","volume":"2","year":"2001","unstructured":"Ornitz DM, Itoh N -2001-. Fibroblast growth factors. Genome Biol 2:REVIEWS3005.","journal-title":"Genome Biol"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910508401112"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.15.2332"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1677\/erc.0.0070165"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2000.0144"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.104.1.77"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/5007"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.1998.tb02166.x"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.250703"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2004.09.012"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000159570.01327.ED"},{"key":"e_1_3_3_34_1","doi-asserted-by":"crossref","unstructured":"Wilkinson DG editor -1998-. In situ hybridization: a practical approach. 2nd rev. ed. Oxford UK: Oxford University Press.","DOI":"10.1093\/oso\/9780199636594.001.0001"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1988.tb01332.x"},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004410051264"},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.8.24.3032"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02307"},{"key":"e_1_3_3_39_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00491"}],"container-title":["Journal of Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/154405910808700307","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/154405910808700307","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/154405910808700307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:04:11Z","timestamp":1777496651000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/154405910808700307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1177\/154405910808700307"],"URL":"https:\/\/doi.org\/10.1177\/154405910808700307","relation":{},"ISSN":["0022-0345","1544-0591"],"issn-type":[{"value":"0022-0345","type":"print"},{"value":"1544-0591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}