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However, once degenerative changes start in the TMJ, this pathology can be crippling, leading to a variety of morphological and functional deformities. Primarily, TMJ disorders have a non-inflammatory origin. The pathological process is characterized by deterioration and abrasion of articular cartilage and local thickening. These changes are accompanied by the superimposition of secondary inflammatory changes. Therefore, appreciating the pathophysiology of the TMJ degenerative disorders is important to an understanding of the etiology, diagnosis, and treatment of internal derangement and osteoarthrosis of the TMJ. The degenerative changes in the TMJ are believed to result from dysfunctional remodeling, due to a decreased host-adaptive capacity of the articulating surfaces and\/or functional overloading of the joint that exceeds the normal adaptive capacity. This paper reviews etiologies that involve biomechanical and biochemical factors associated with functional overloading of the joint and the clinical, radiographic, and biochemical findings important in the diagnosis of TMJ-osteoarthrosis. In addition, non-invasive and invasive modalities utilized in TMJ-osteoarthrosis management, and the possibility of tissue engineering, are discussed.<\/jats:p>","DOI":"10.1177\/154405910808700406","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"296-307","source":"Crossref","is-referenced-by-count":765,"title":["Degenerative Disorders of the Temporomandibular Joint: Etiology, Diagnosis, and Treatment"],"prefix":"10.1177","volume":"87","author":[{"given":"E.","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics, The University of Tokushima Graduate School of Oral Sciences, 3-18-15 Kuramoto-cho, Tokushima 770-8504, Japan;"},{"name":"Department of Chemical and Petroleum Engineering, University of Kansas, Lawrence, KS, USA; and"},{"name":"Department of Surgery, Division of Oral and Maxillofacial Surgery, Stritch School of Medicine, Loyola University Medical Center, Maywood, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.S.","family":"Detamore","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics, The University of Tokushima Graduate School of Oral Sciences, 3-18-15 Kuramoto-cho, Tokushima 770-8504, Japan;"},{"name":"Department of Chemical and Petroleum Engineering, University of Kansas, Lawrence, KS, USA; and"},{"name":"Department of Surgery, Division of Oral and Maxillofacial Surgery, Stritch School of Medicine, Loyola University Medical Center, Maywood, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.G.","family":"Mercuri","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics, The University of Tokushima Graduate School of Oral Sciences, 3-18-15 Kuramoto-cho, Tokushima 770-8504, Japan;"},{"name":"Department of Chemical and Petroleum Engineering, University of Kansas, Lawrence, KS, USA; and"},{"name":"Department of Surgery, Division of Oral and Maxillofacial Surgery, Stritch School of Medicine, Loyola University Medical Center, Maywood, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2008,4,1]]},"reference":[{"key":"ABUKAWA-ETAL-2003","doi-asserted-by":"crossref","unstructured":"Abukawa H, Terai H, Hannouche D, Vacanti JP, Kaban LB, Troulis MJ -2003- Formation of a mandibular condyle in vitro by tissue engineering. 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