{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:37:42Z","timestamp":1791286662820,"version":"4.1.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:p>During orthodontic tooth movement, bone resorption occurs at the compression site. However, the mechanism underlying resorption remains unclear. Applying compressive force to human osteoblast-like cells grown in a 3D collagen gel, we examined gene induction by using microarray and RT-PCR analysis. Among 43 genes exhibiting significant changes, cyclo-oxygenase-2, ornithine decarboxylase, and matrix metalloproteinase-3 (MMP-3) were up-regulated, whereas membrane-bound interleukin-1 receptor accessory protein was down-regulated. The MMP-3 protein increases were further confirmed by Western blot. To ascertain whether MMP-3 is up-regulated in vivo by orthodontic force, we examined human bone samples at the compressive site by realigning the angulated molars. Immunohistochemical staining revealed MMP-3 distributed along the compressive site of the bony region within 3 days of compression. Since MMP-3 participates in degradation of a wide range of extracellular matrix molecules, we propose that MMP-3 plays an important role in bone resorption during orthodontic tooth movement.<\/jats:p>","DOI":"10.1177\/154405910808700714","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"692-696","source":"Crossref","is-referenced-by-count":25,"title":["MMP-3 Response to Compressive Forces\n                    <i>in vitro<\/i>\n                    and\n                    <i>in vivo<\/i>"],"prefix":"10.1177","volume":"87","author":[{"given":"H.-H.","family":"Chang","sequence":"first","affiliation":[{"name":"School of Dentistry, National Taiwan University, Taiwan;"},{"name":"Dental Department, National Taiwan University Hospital, Taiwan;"},{"name":"Department of Orthodontics, Chang-Gung Memorial Hospital, and College of Medicine, Chang-Gung University; and"},{"name":"Graduate Institute of Oral Biology, National Taiwan University, 1 Chang-Te Street, Taipei 100, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.-B.","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Dentistry, National Taiwan University, Taiwan;"},{"name":"Dental Department, National Taiwan University Hospital, Taiwan;"},{"name":"Department of Orthodontics, Chang-Gung Memorial Hospital, and College of Medicine, Chang-Gung University; 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