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Msx1, Pax9, and Axin2 are involved in non-syndromic hypodontia, while genes such as Shh, Pitx2, Irf6, and p63 are considered to participate in syndromic genetic disorders, which include tooth agenesis. In dentistry, artificial tooth implants represent a common solution to tooth loss problems; however, molecular dentistry offers promising solutions for the future. In this paper, the genetic and molecular bases of non-syndromic and syndromic hypodontia are reviewed, and the advantages and disadvantages of tissue engineering in the clinical treatment of tooth agenesis are discussed.<\/jats:p>","DOI":"10.1177\/154405910808700715","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"617-623","source":"Crossref","is-referenced-by-count":172,"title":["Tooth Agenesis: from Molecular Genetics to Molecular Dentistry"],"prefix":"10.1177","volume":"87","author":[{"given":"E.","family":"Matalova","sequence":"first","affiliation":[{"name":"Laboratory of Animal Embryology, Institute of Animal Physiology and Genetics, Academy of Sciences, Brno, Czech Republic;"},{"name":"Department of Animal Physiology, Faculty of Sciences, University of South Bohemia, Ceske Budejovice, Czech Republic;"},{"name":"Department of Physiology and Pathophysiology, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic; and"},{"name":"Department of Craniofacial Development, Dental Institute, Kings College London, Guys Hospital, London Bridge, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Fleischmannova","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Embryology, Institute of Animal Physiology and Genetics, Academy of Sciences, Brno, Czech Republic;"},{"name":"Department of Animal Physiology, Faculty of Sciences, University of South Bohemia, Ceske Budejovice, Czech Republic;"},{"name":"Department of Physiology and Pathophysiology, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic; and"},{"name":"Department of Craniofacial Development, Dental Institute, Kings College London, Guys Hospital, London Bridge, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.T.","family":"Sharpe","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Embryology, Institute of Animal Physiology and Genetics, Academy of Sciences, Brno, Czech Republic;"},{"name":"Department of Animal Physiology, Faculty of Sciences, University of South Bohemia, Ceske Budejovice, Czech Republic;"},{"name":"Department of Physiology and Pathophysiology, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic; and"},{"name":"Department of Craniofacial Development, Dental Institute, Kings College London, Guys Hospital, London Bridge, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.S.","family":"Tucker","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Embryology, Institute of Animal Physiology and Genetics, Academy of Sciences, Brno, Czech Republic;"},{"name":"Department of Animal Physiology, Faculty of Sciences, University of South Bohemia, Ceske Budejovice, Czech Republic;"},{"name":"Department of Physiology and Pathophysiology, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic; and"},{"name":"Department of Craniofacial Development, Dental Institute, Kings College London, Guys Hospital, London Bridge, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2008,7,1]]},"reference":[{"key":"ADELL-ETAL-1990","unstructured":"Adell R, Eriksson B, Lekholm U, Br\u00e5nemark PI, Jemt T -1990- Long-term follow-up study of osseointegrated implants in the treatment of totally edentulous jaws. 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