{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T16:18:25Z","timestamp":1794327505323,"version":"4.9.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:p>\n                    The anticaries effect of professional fluoride (F) application has been attributed to calcium-fluoride-like deposits (CaF\n                    <jats:sub>2<\/jats:sub>\n                    ) formed on enamel, but this has not been clearly demonstrated. We hypothesized that CaF\n                    <jats:sub>2<\/jats:sub>\n                    formed on plaque-free enamel by F application would reduce enamel demineralization due to the increase of F availability in fluid of subsequently formed plaque. We created distinct levels of CaF\n                    <jats:sub>2<\/jats:sub>\n                    on enamel to evaluate a dose-response effect. Enamel blocks were mounted in contact with a S. mutans test plaque and used in situ by 10 volunteers. F released to the fluid phase of this substrate (\u201cplaque fluid\u201d) was measured before a cariogenic challenge. \u201cPlaque fluid\u201d F concentration was highly correlated to the enamel CaF\n                    <jats:sub>2<\/jats:sub>\n                    concentration (r = 0.96, p &lt; 0.001) and to consequent enamel demineralization (r = \u22120.75, p &lt; 0.001). The results suggest that F released to plaque fluid from CaF\n                    <jats:sub>2<\/jats:sub>\n                    formed on enamel may play a significant role in the anticaries effect of professionally applied F agents.\n                  <\/jats:p>","DOI":"10.1177\/154405910808701105","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"1032-1036","source":"Crossref","is-referenced-by-count":65,"title":["Fluoride Release from CaF\n                    <sub>2<\/sub>\n                    and Enamel Demineralization"],"prefix":"10.1177","volume":"87","author":[{"given":"L.M.A.","family":"Tenuta","sequence":"first","affiliation":[{"name":"Piracicaba Dental School, UNICAMP, Av. Limeira 901, 13414-903, Piracicaba, SP Piracicaba, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.V.","family":"Cerezetti","sequence":"additional","affiliation":[{"name":"Piracicaba Dental School, UNICAMP, Av. Limeira 901, 13414-903, Piracicaba, SP Piracicaba, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.A.","family":"Del Bel Cury","sequence":"additional","affiliation":[{"name":"Piracicaba Dental School, UNICAMP, Av. Limeira 901, 13414-903, Piracicaba, SP Piracicaba, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.P.M.","family":"Tabchoury","sequence":"additional","affiliation":[{"name":"Piracicaba Dental School, UNICAMP, Av. Limeira 901, 13414-903, Piracicaba, SP Piracicaba, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.A.","family":"Cury","sequence":"additional","affiliation":[{"name":"Piracicaba Dental School, UNICAMP, Av. Limeira 901, 13414-903, Piracicaba, SP Piracicaba, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2008,11,1]]},"reference":[{"key":"BOX-ETAL-1978","unstructured":"Box GEP, Hunter WG, Hunter JS -1978- Statistics for experimenters. New York: John Wiley & Sons Inc."},{"key":"BRADSHAW-ETAL-2002","doi-asserted-by":"publisher","DOI":"10.1159\/000057864"},{"key":"CASLAVSKA-ETAL-1975","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(75)90023-0"},{"key":"CURY-ETAL-2003","doi-asserted-by":"publisher","DOI":"10.1159\/000070444"},{"key":"DIJKMAN-ETAL-1983","doi-asserted-by":"publisher","DOI":"10.1159\/000260693"},{"key":"FISKE-AND-SUBBAROW-1925","doi-asserted-by":"crossref","unstructured":"Fiske CH, Subbarow Y -1925- The colorimetric determination of phosphorus. 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In: Factors relating to demineralisation and remineralisation of the teeth. Leach SA, editor. 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