{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T12:35:57Z","timestamp":1777811757579,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:p>\n                    Nitric oxide (NO) derived from inducible nitric oxide synthase (iNOS) plays an important role in host defense, as well as in inflammation-induced tissue lesions. Here we evaluated the role of NO in bone loss in bacterial infection-induced apical periodontitis by using iNOS-deficient mice (iNOS\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ). The iNOS\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice developed greater inflammatory cell recruitment and osteolytic lesions than WT mice. Moreover, tartrate-resistant acid-phosphatase-positive (TRAP\n                    <jats:sup>+<\/jats:sup>\n                    ) osteoclasts were significantly more numerous in iNOS\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice. Furthermore, the increased bone resorption in iNOS\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice also correlated with the increased expression of receptor activator NF-kappaB (RANK), stromal-cell-derived factor-1\u03b1 (SDF-1\u03b1\/CXCL12), and reduced expression of osteoprotegerin (OPG). These results show that NO deficiency was associated with an imbalance of bone-resorption-modulating factors, leading to severe infection-stimulated bone loss.\n                  <\/jats:p>","DOI":"10.1177\/154405910808701207","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"1155-1159","source":"Crossref","is-referenced-by-count":60,"title":["iNOS -derived Nitric Oxide Modulates Infection-stimulated Bone Loss"],"prefix":"10.1177","volume":"87","author":[{"given":"S.Y.","family":"Fukada","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Av. Bandeirantes 3900, Monte Alegre, 14049-900, Ribeir\u00e3o Preto SP, S\u00e3o Paulo, Brazil;"},{"name":"Department of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil;"},{"name":"Department of Biological Sciences, School of Dentistry of Bauru, University of S\u00e3o Paulo, Bauru, S\u00e3o Paulo, Brazil;"},{"name":"Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, S\u00e3o Paulo, Brazil; and"},{"name":"Department of Biochemistry and Immunology, School of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.A.","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Av. Bandeirantes 3900, Monte Alegre, 14049-900, Ribeir\u00e3o Preto SP, S\u00e3o Paulo, Brazil;"},{"name":"Department of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil;"},{"name":"Department of Biological Sciences, School of Dentistry of Bauru, University of S\u00e3o Paulo, Bauru, S\u00e3o Paulo, Brazil;"},{"name":"Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, S\u00e3o Paulo, Brazil; and"},{"name":"Department of Biochemistry and Immunology, School of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.F.","family":"Saconato","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Av. Bandeirantes 3900, Monte Alegre, 14049-900, Ribeir\u00e3o Preto SP, S\u00e3o Paulo, Brazil;"},{"name":"Department of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil;"},{"name":"Department of Biological Sciences, School of Dentistry of Bauru, University of S\u00e3o Paulo, Bauru, S\u00e3o Paulo, Brazil;"},{"name":"Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, S\u00e3o Paulo, Brazil; and"},{"name":"Department of Biochemistry and Immunology, School of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.P.","family":"Garlet","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Av. Bandeirantes 3900, Monte Alegre, 14049-900, Ribeir\u00e3o Preto SP, S\u00e3o Paulo, Brazil;"},{"name":"Department of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil;"},{"name":"Department of Biological Sciences, School of Dentistry of Bauru, University of S\u00e3o Paulo, Bauru, S\u00e3o Paulo, Brazil;"},{"name":"Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, S\u00e3o Paulo, Brazil; and"},{"name":"Department of Biochemistry and Immunology, School of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.J.","family":"\u00c1vila-Campos","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Av. Bandeirantes 3900, Monte Alegre, 14049-900, Ribeir\u00e3o Preto SP, S\u00e3o Paulo, Brazil;"},{"name":"Department of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil;"},{"name":"Department of Biological Sciences, School of Dentistry of Bauru, University of S\u00e3o Paulo, Bauru, S\u00e3o Paulo, Brazil;"},{"name":"Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, S\u00e3o Paulo, Brazil; and"},{"name":"Department of Biochemistry and Immunology, School of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.S.","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Av. Bandeirantes 3900, Monte Alegre, 14049-900, Ribeir\u00e3o Preto SP, S\u00e3o Paulo, Brazil;"},{"name":"Department of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil;"},{"name":"Department of Biological Sciences, School of Dentistry of Bauru, University of S\u00e3o Paulo, Bauru, S\u00e3o Paulo, Brazil;"},{"name":"Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, S\u00e3o Paulo, Brazil; and"},{"name":"Department of Biochemistry and Immunology, School of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.Q.","family":"Cunha","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Av. 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