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In 1970, Ivanyi and Lehner highlighted a possible role for cell-mediated immunity, which stimulated a flurry of activity centered on the role of lymphokines such as osteoclast-activating factor (OAF), macrophage-activating factor (MAF), macrophage migration inhibition factor (MIF), and myriad others. In the late 1970s and early 1980s, attention focused on the role of polymorphonuclear neutrophils, and it was thought that periodontal destruction occurred as a series of acute exacerbations. As well, at this stage doubt was being cast on the concept that there was a neutrophil chemotactic defect in periodontitis patients. Once it was realized that neutrophils were primarily protective and that severe periodontal destruction occurred in the absence of these cells, attention swung back to the role of lymphocytes and in particular the regulatory role of T-cells. By this time in the early 1990s, while the roles of interleukin (IL)-1, prostaglandin (PG) E<jats:sub>2<\/jats:sub>, and metalloproteinases as the destructive mediators in periodontal disease were largely understood, the control and regulation of these cytokines remained controversial. With the widespread acceptance of the Th1\/Th2 paradigm, the regulatory role of T-cells became the main focus of attention. Two apparently conflicting theories have emerged. One is based on direct observations of human lesions, while the other is based on animal model experiments and the inability to demonstrate IL-4 mRNA in gingival extracts. As part of the \"Controversy\" series, this review is intended to stimulate debate and hence may appear in some places provocative. In this context, this review will present the case that destructive periodontitis is due to the nature of the lymphocytic infiltrate and is not due to periodic acute exacerbations, nor is it due to the so-called virulence factors of putative periodontal pathogens. <\/jats:p>","DOI":"10.1177\/154411130201300104","type":"journal-article","created":{"date-parts":[[2009,1,9]],"date-time":"2009-01-09T00:40:32Z","timestamp":1231461632000},"page":"17-34","source":"Crossref","is-referenced-by-count":160,"title":["D<scp>estructive<\/scp> P<scp>eriodontitis<\/scp> L<scp>esions are<\/scp> D<scp>etermined by the<\/scp> N<scp>ature of the<\/scp> L<scp>ymphocytic<\/scp> R<scp>esponse<\/scp>"],"prefix":"10.1177","volume":"13","author":[{"given":"E.","family":"Gemmell","sequence":"first","affiliation":[{"name":"School of Dentistry, The University of Queensland, Brisbane 4072, Australia; and"},{"name":"Faculty of Dentistry, Niigata University, Niigata 951-8514, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"School of Dentistry, The University of Queensland, Brisbane 4072, Australia; and"},{"name":"Faculty of Dentistry, Niigata University, Niigata 951-8514, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.J.","family":"Seymour","sequence":"additional","affiliation":[{"name":"School of Dentistry, The University of Queensland, Brisbane 4072, Australia; and"},{"name":"Faculty of Dentistry, Niigata University, Niigata 951-8514, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2002,1,1]]},"reference":[{"key":"ANDERSON-ETAL-1995","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.63.9.3245-3252.1995"},{"key":"AOYAGI-ETAL-1995","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1995.tb00159.x"},{"key":"ASHKENAZI-ETAL-1992A","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1992.tb01677.x"},{"key":"ASHKENAZI-ETAL-1992B","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1992.tb01818.x"},{"key":"ATTSTROM-AND-SCHROEDER-1979","doi-asserted-by":"crossref","unstructured":"Attstr\u00f6m R, Schroeder HE (1979). 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