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Those metallic components may be locally and systemically distributed and could play a role in the etiology of oral and systemic pathological conditions. The quality and quantity of the released cations depend upon the type of alloy and various corrosion parameters. No general correlation has been observed between alloy nobility and corrosion. However, it has been documented that some Ni-based alloys, such as beryllium-containing Ni alloys, exhibit increased corrosion, specifically at low pH. Further, microparticles are abraded from metallic restorations due to wear. In sufficient quantities, released metal ions\u2014particularly Cu, Ni, Be, and abraded microparticles\u2014can also induce inflammation of the adjacent periodontal tissues and the oral mucosa. While there is also some in vitro evidence that the immune response can be altered by various metal ions, the role of these ions in oral inflammatory diseases such as gingivitis and periodontitis is unknown. Allergic reactions due to metallic dental restorations have been documented. Ni has especially been identified as being highly allergenic. Interestingly, from 34% to 65.5% of the patients who are allergic to Ni are also allergic to Pd. Further, Pd allergy always occurrs with Ni sensitivity. In contrast, no study has been published which supports the hypothesis that dental metallic materials are mutagenic\/genotoxic or might be a carcinogenic hazard to man. Taken together, very contradictory data have been documented regarding the local and systemic effects of dental casting alloys and metallic ions released from them. Therefore, it is of critical importance to elucidate the release of cations from metallic dental restorations in the oral environment and to determine the biological interactions of released metal components with oral and systemic tissues.<\/jats:p>","DOI":"10.1177\/154411130201300108","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:40:32Z","timestamp":1231443632000},"page":"71-84","source":"Crossref","is-referenced-by-count":187,"title":["B\n                    <scp>iocompatibility of<\/scp>\n                    D\n                    <scp>ental<\/scp>\n                    C\n                    <scp>asting<\/scp>\n                    A\n                    <scp>lloys<\/scp>"],"prefix":"10.1177","volume":"13","author":[{"given":"Werner","family":"Geurtsen","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Periodontology, Medical University Hannover, D-30623 Hannover, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2002,1,1]]},"reference":[{"key":"ABDALLAH-ETAL-1994","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(94)90228-3"},{"key":"ABERER-ETAL-1993","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1993.tb03379.x"},{"key":"ALLER-1990","unstructured":"Aller AJ (1990). 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